SMC1A

Gene Symbol SMC1A
Entrez Gene 8243
Alt Symbol CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Species Human
Gene Type protein-coding
Description structural maintenance of chromosomes 1A
Other Description SMC protein 1A|SMC-1-alpha|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|segregation of mitotic chromosomes 1|structural maintenance of chromosomes protein 1A
Swissprots Q16351 Q2M228 O14995 Q14683
Accessions CAI42089 CAI42645 CAI42646 EAW93149 EAW93150 EAW93151 Q14683 AF176781 AAQ13659 AK055575 AK056308 AK091458 AK291921 BAF84610 AK301266 BAH13445 BC064368 AAH64368 BC080185 AAH80185 BC112127 AAI12128 BC171726 BP312805 BQ232418 BX640922 CAE45960 D80000 BAA11495 HQ258690 ADR83441 S78271 AAB34405 NM_001281463 NP_001268392 NM_006306 NP_006297
Function Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12199140}. Chromosome {ECO:0000269|PubMed:12199140}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12199140}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere- kinetochore complex at the kinetochore region during mitosis.
Top Pathways Cell cycle, Oocyte meiosis

Phospho-SMC1 (Ser957) Antibody - 4801 from Cell Signaling Technology

Prices $279.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, untreated or UV-treated, using Phospho-SMC1 (Ser957) Antibody (upper) or SMC1 Antibody #4802 (lower).

Phospho-SMC1 (Ser360) Antibody - 4029 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, untreated or UV-treated (100 J/m 2 followed by 4 hour recovery) using Phospho-SMC1 (Ser360) Antibody (upper) or SMC1 Antibody #4802 (lower). Antibody phospho-specificity was determined by treating cell extracts with λ phosphatase.

Phospho-SMC1 (Ser957) (5D11G5) Mouse mAb - 4805 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 5D11G5
Western blot analysis of extracts from 293 and NIH/3T3 cells, untreated or UV-treated, using Phospho-SMC1 (Ser957) (5D11G5) Mouse Monoclonal Antibody (upper), SMC1 Antibody #4802 (middle), and DNA-PK Antibody #4602 (lower).

SMC1 (8E6) Mouse mAb - 6892 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 8E6
Western blot analysis of extracts from various cell lines using SMC1 (8E6) Mouse mAb.

SMC1 Antibody - 4802 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, untreated or UV-treated, using Phospho-SMC1 (Ser957) Antibody #4801 (upper) or SMC1 Antibody (lower).

SMC1 (P-17) - sc-21078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SMC1 (P-17): sc-21078. Immunoperoxidase staining of formalin fixed, paraffin-embedded human oral mucosa tissue showing nuclear staining of squamous epithelial cells.

SMC1 (E-19) - sc-10706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMC1 (C2M) - sc-56776 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SMC1 (C2M): sc-56776. Western blot analysis of SMC1 expression in A-431 nuclear extract.

SMC1α (C-17) - sc-10707 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SMC1α (C-17): sc-10707. Western blot analysis of SMC1α expression in U-937 (A), K-562 (B), NIH/3T3 (C), MOLT-4 (D), Jurkat (E) and HL-60 (F) nuclear extracts.

SMC1α (E-8) - sc-166734 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SMC1α (E-8): sc-166734. Western blot analysis of SMC1α expression in Jurkat nuclear extract.

SMC1α (H-6) - sc-393171 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SMC1α (H-6): sc-393171. Western blot analysis of SMC1α expression in K-562 (A), Jurkat (B), U-937 (C), NIH/3T3 (D), MOLT-4 (E) and HL-60 (F) nuclear extracts.

SMC1α (H-120) - sc-25387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SMC1α (H-120): sc-25387. Western blot analysis of SMC1α expression in HeLa (A), K-562 (B), NIH/3T3 (C), A-431 (D) and Jurkat (E) nuclear extracts.

SMC1α (I-19) - sc-30959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SMC1α (I-19): sc-30959. Western blot analysis of SMC1α expression in A-431 (A), Jurkat (B) and HL-60 (C) nuclear extracts.

SMC1α (K-20) - sc-30960 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMC1α (M-16) - sc-30958 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SMC1α (M-16): sc-30958. Western blot analysis of SMC1α expression in HeLa (A), K-562 (B), NIH/3T3 (C) and A-431 (D) nuclear extracts.

p-SMC1 (Ser 957) - sc-68746 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

p-SMC1 (Ser 957) - sc-135652 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-SMC1 (Ser 957): sc-135652. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung carcinoma tissue showing nuclear localization.

p-SMC1α (30.Ser 966) - sc-135783 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of SMC1α phosphorylation in untreated (A,D), UV irradiated (B,E) and UV irradiated and lambda protein phosphatase (sc-200312A) treated (C,F) HeLa whole cell lysates. Antibodies tested include p-SMC1α (30.Ser 966): sc-135783 (A,B,C) and SMC1α (M-16): sc-30958 (D,E,F).

p-SMC1α (43.Ser 966) - sc-135784 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of SMC1α phosphorylation in untreated (A,D), UV irradiated (B,E) and UV irradiated and lambda protein phosphatase (sc-200312A) treated (C,F) HeLa whole cell lysates. Antibodies tested include p-SMC1α (43.Ser 966): sc-135784 (A,B,C) and SMC1α (M-16): sc-30958 (D,E,F).

Anti-SMC1A (phospho S957) antibody - ab194759 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SMC1A (phospho S957) antibody (ab194759) at 1/500 dilutionLane 1 : 293 cell extractLane 2 : UV treated 293 cell extract

Anti-SMC1A antibody - ab126794 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SMC1A antibody (ab126794) at 1/1000 dilutionLane 1 : HeLa cell lysate at 3 µgLane 2 : HeLa cell lysate at 10 µgLane 3 : HeLa cell lysate at 30 µg

Anti-SMC1A antibody - ab116720 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SMC1A antibody (ab116720) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-SMC1A antibody [1B9] - ab117610 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1B9
ab117610 at 5 µg/ml staining SMC1A in Formalin-fixed, Paraffin-Embedded Human Prostate tissue by Immunohistochemistry.

Anti-SMC1A antibody [4C5-C8-A11] - ab131201 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C5-C8-A11
Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using anti-SMC1A mouse mAb(1:100).

Anti-SMC1A antibody [5B6] - ab130222 from Abcam

Host Mouse
Clonality Monoclonal
Clone 5B6
All lanes : Anti-SMC1A antibody [5B6] (ab130222) at 1/500 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLane 3 : A549 cell lysate
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