IKBKG

Gene Symbol	IKBKG
Entrez Gene	8517
Alt Symbol	AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9
Species	Human
Gene Type	protein-coding
Description	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Other Description	I-kappa-B kinase subunit gamma|IKKAP1|IKKG|IkB kinase gamma subunit|NF-kappa-B essential modifier|NF-kappa-B essential modulator|NFkappaB essential modulator|ikB kinase subunit gamma|ikB kinase-associated protein 1|incontinentia pigmenti|inhibitor of nuclear factor kappa-B kinase subunit gamma
Swissprots	Q7Z7F1 Q7LBY6 Q9Y6K9
Accessions	AAL27012 CAB93146 EAW72677 EAW72678 EAW72679 EAW72680 EAW72681 Q9Y6K9 AF062089 AAD12183 AF074382 AAC36330 AF091453 AAD38081 AF261086 AAF99679 AK000593 AK308366 AY114157 AAM44073 AY429546 AY429547 AY429548 BC000299 AAH00299 BC012114 AAH12114 BC046922 AAH46922 BC050612 AAH50612 BT019621 AAV38427 DC410130 DQ891383 ABM82309 DQ894560 ABM85486 XM_005274760 XP_005274817 XM_005274761 XP_005274818 XM_005274764 XP_005274821 XM_011531203 XP_011529505 XM_011531204 XP_011529506 XM_011531205 XP_011529507 XM_011531206 XP_011529508 XM_011531207 XP_011529509 NM_001099856 NP_001093326 NM_001099857 NP_001093327 NM_001145255 NP_001138727 NM_003639 NP_003630
Function	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:14651848}. Nucleus {ECO:0000269|PubMed:14651848}. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways	Herpes simplex infection, Viral carcinogenesis, PI3K-Akt signaling pathway, HTLV-I infection, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IKKγ CRISPR/Cas9 KO Plasmid (h) - sc-400274 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKγ HDR Plasmid (h) - sc-400274-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKγ Double Nickase Plasmid (h) - sc-400274-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKγ Double Nickase Plasmid (h2) - sc-400274-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKγ CRISPR Activation Plasmid (h) - sc-400274-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKγ CRISPR Activation Plasmid (h2) - sc-400274-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKγ Lentiviral Activation Particles (h) - sc-400274-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKγ Lentiviral Activation Particles (h2) - sc-400274-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKKγ siRNA (h) - sc-29363 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKKγ shRNA Plasmid (h) - sc-29363-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKKγ shRNA (h) Lentiviral Particles - sc-29363-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKK gamma RNAi - H00008517-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU032271 from Sigma-Aldrich Category siRNA

MISSION® siRNA - SIHK0960 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0958 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0959 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0957 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN10555 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10555 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04456 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04456

IKBKG siRNA (Human) - CRH5590 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IKBKG - MBS8212134 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IKBKG(NM_003639.3) - SHL169842 from Creative biogene Category siRNA Species Reactivities Human

Human IKBKG siRNA - orb266092 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IKBKG shRNA Plasmid (Human) - CHH5590 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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