IKBKG

Gene Symbol	IKBKG
Entrez Gene	8517
Alt Symbol	AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9
Species	Human
Gene Type	protein-coding
Description	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Other Description	I-kappa-B kinase subunit gamma|IKKAP1|IKKG|IkB kinase gamma subunit|NF-kappa-B essential modifier|NF-kappa-B essential modulator|NFkappaB essential modulator|ikB kinase subunit gamma|ikB kinase-associated protein 1|incontinentia pigmenti|inhibitor of nuclear factor kappa-B kinase subunit gamma
Swissprots	Q7Z7F1 Q7LBY6 Q9Y6K9
Accessions	AAL27012 CAB93146 EAW72677 EAW72678 EAW72679 EAW72680 EAW72681 Q9Y6K9 AF062089 AAD12183 AF074382 AAC36330 AF091453 AAD38081 AF261086 AAF99679 AK000593 AK308366 AY114157 AAM44073 AY429546 AY429547 AY429548 BC000299 AAH00299 BC012114 AAH12114 BC046922 AAH46922 BC050612 AAH50612 BT019621 AAV38427 DC410130 DQ891383 ABM82309 DQ894560 ABM85486 XM_005274760 XP_005274817 XM_005274761 XP_005274818 XM_005274764 XP_005274821 XM_011531203 XP_011529505 XM_011531204 XP_011529506 XM_011531205 XP_011529507 XM_011531206 XP_011529508 XM_011531207 XP_011529509 NM_001099856 NP_001093326 NM_001099857 NP_001093327 NM_001145255 NP_001138727 NM_003639 NP_003630
Function	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:14651848}. Nucleus {ECO:0000269|PubMed:14651848}. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways	Herpes simplex infection, Viral carcinogenesis, PI3K-Akt signaling pathway, HTLV-I infection, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Phospho-IKBKG / NEMO / IKK Gamma (Ser31) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1145 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.78-50 ng/ml

Human IKBKG / NEMO / IKK Gamma ELISA Kit (Cell-Based ELISA) - LS-F2073 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.78-50 ng/ml

Human Phospho-IKBKG / NEMO / IKK Gamma (Ser85) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1418 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.78-50 ng/ml

Human IKBKG / NEMO / IKK Gamma ELISA Kit (Sandwich ELISA) - LS-F12135 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.78-50 ng/ml

NF-kappa-B essential modulator, IKBKG, Human, ELISA Kit - E9868h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.78-50 ng/mL

Prostacyclin Receptor (PTGIR), Human, ELISA Kit - SEC929Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.071ng/mL Range 0.156-10ng/mL

Human IP-2 ELISA Kit - HC0041 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human IP-1 ELISA Kit - HC0040 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine IP-1 ELISA Kit - AC0040 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine IP-2 ELISA Kit - AC0041 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, ELISA Kit - MBS9323009 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml. Range 62.5 pg/ml - 2000 pg/ml.

IKK-gamma Colorimetric Cell-Based ELISA Kit - CB5360 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

IKK-gamma (Phospho-Ser31) Colorimetric Cell-Based ELISA Kit - CBP1129 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

IKK-gamma (Phospho-Ser85) Colorimetric Cell-Based ELISA Kit - CBP1450 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

ELISA Kit for Prostacyclin Receptor (PTGIR) - SEC929Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.056ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse IKBKG / NEMO / IKK Gamma ELISA Kit (Custom ELISA) - LS-F20599 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Bovine IKBKG / NEMO / IKK Gamma ELISA Kit (Custom ELISA) - LS-F20601 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Rat IKBKG / NEMO / IKK Gamma ELISA Kit (Custom ELISA) - LS-F20600 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Human NF-kappa-B essential modulator ELISA Kit - abx251895 from Abbexa Category ELISA Kit Range 0.78 ng/ml - 50 ng/ml

Prostacyclin Receptor (PTGIR), Human, ELISA Kit - DL-PTGIR-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

IKK-gamma ELISA Kit - DEIA-XYA1040 from Creative Diagnostics Category ELISA Kit

IKK-gamma (Phospho-Ser31) ELISA Kit - DEIA-XYA1041 from Creative Diagnostics Category ELISA Kit

IKK-gamma (Phospho-Ser85) ELISA Kit - DEIA-XYA1042 from Creative Diagnostics Category ELISA Kit

Human NF-kappa-B essential modulator ELISA Kit - EKE54972 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.34 ng/mL Range 0.78-50 ng/mL

IKBKG - EKH5046 from Nordic BioSite Sensitivity 0.469ng/ml Range 0.78-50ng/ml

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