AZIN2

Gene Symbol AZIN2
Entrez Gene 113451
Alt Symbol ADC, AZI2, AZIB1, ODC-p, ODC1L, ODCp
Species Human
Gene Type protein-coding
Description antizyme inhibitor 2
Other Description ODC antizyme inhibitor-2|ODC-like protein|ODC-paralogue|arginine decarboxylase|ornithine decarboxylase like|ornithine decarboxylase paralog|ornithine decarboxylase-like protein|ornithine decarboxylase-paralog
Swissprots Q5TIF5 Q96MD9 Q8TF56 Q5TIF4 Q96L57 Q96L55 D3DPQ9 Q96L54 Q96A70 Q96L56 Q5TIF6 B2RDU5
Accessions CAD48798 EAX07469 EAX07470 EAX07471 EAX07472 EAX07473 EAX07474 EAX07475 EAX07476 EAX07477 EAX07478 EAX07479 EAX07480 EAX07481 EAX07482 Q96A70 AB075825 BAB85531 AK057051 BAB71356 AK095127 BAC04489 AK122697 BAG53674 AK315677 BAG38042 AL832640 AW450278 AY050634 AAL08049 AY050635 AAL08050 AY050636 AAL08051 AY050637 AAL08052 AY050638 AAL08053 AY325129 AAQ62560 BC010449 AAH10449 BC028128 AAH28128 DB456925 DQ892054 ABM82980 DQ895248 ABM86174 XM_005270404 XP_005270461 XM_005270406 XP_005270463 XM_005270407 XP_005270464 XM_006710311 XP_006710374 XM_006710312 XP_006710375 XM_011540557 XP_011538859 XM_011540558 XP_011538860 XM_011540559 XP_011538861 XM_011540560 XP_011538862 XM_011540561 XP_011538863 XM_011540562 XP_011538864 XM_011540563 XP_011538865 XM_011540564 XP_011538866 XM_011540565 XP_011538867 XM_011540566 XP_011538868 XR_946531 NM_001293562 NP_001280491 NM_001301823 NP_001288752 NM_001301824 NP_001288753 NM_001301825 NP_001288754 NM_001301826 NP_001288755 NM_052998 NP_443724 NR_126031
Function Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728). {ECO:0000269|PubMed:14738999, ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:20188728}.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Membrane {ECO:0000250}. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme-dependent manner. Localizes with vesicle- associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. {ECO:0
Tissue Specificity Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis. {ECO:0000269|PubMed:11587527, ECO:0000269|PubMed:14738999, ECO:0000269|PubMed:19718454, ECO:0000269|PubMed:19756694, ECO:0000269|PubMed:19832840}.
Top Pathways Arginine and proline metabolism

ODCp (E-14) - sc-104492 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ODCp (E-14): sc-104492. Western blot analysis of ODCp expression in HeLa whole cell lysate.

ODCp (G-16) - sc-104494 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ODCp (G-16): sc-104494. Western blot analysis of ODCp expression in HeLa whole cell lysate.

ODCp (H-67) - sc-366545 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ODCp (S-17) - sc-104495 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ODCp (S-17): sc-104495. Western blot analysis of ODCp expression in HeLa whole cell lysate.

Anti-L-Arginine decarboxylase antibody [EPR7124(2)] - ab157214 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7124(2)
Overlay histogram showing SH-SY5Y cells stained with ab157214 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab157214, 1/100 dilution) for 30 min at 22ºC. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22ºC. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-AZIN2 / Antizyme Inhibitor 2 Antibody (aa179-228) - LS-C116488 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ADC antibody LS-C116488 Western blot of COLO205 cell lysate.

Anti-AZIN2 / Antizyme Inhibitor 2 Antibody (aa274-323) - LS-C186694 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Liver Tumor. ADC antibody dilution 1.0 ug/ml.

Anti-AZIN2 / Antizyme Inhibitor 2 Antibody (Internal) IHC-plus™ - LS-B10875 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Arginine Decarboxylase / ADC antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Arginine decarboxylase Antibody - NBP1-82878 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Arginine decarboxylase Antibody [NBP1-82878] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

Arginine decarboxylase Antibody - NBP1-70403 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Arginine decarboxylase Antibody - NBP1-82879 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Arginine decarboxylase Antibody [NBP1-82879] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4

AZI2 Antibody - NBP1-88924 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: AZI2 Antibody [NBP1-88924] - Staining of human cell line A-431 shows positivity in plasma membrane and cytoplasm.

Arginine decarboxylase Antibody - NBP2-15447 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Arginine decarboxylase Antibody [NBP2-15447] - Sample (30 ug of whole cell lysate) A: U87-MG 10% SDS PAGE gel, diluted at 1:5000.

Anti-ADC antibody produced in rabbit - SAB2105840 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ADC: <B>Cat. No. SAB2105840</B>: ADC in COLO205 cell lysates with ADC antibody at 1.0 μg/mL.

Anti-ADC antibody produced in rabbit - HPA028527 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ADC: <B>Cat. No. HPA028527</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

Anti-ADC antibody produced in rabbit - HPA028045 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ADC: <B>Cat. No. HPA028045</B>: Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.

ADC antibody - middle region (ARP52476_P050) - ARP52476_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ADC Antibody - C-terminal region (ARP52477_P050) - ARP52477_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ADC antibody [N2C2], Internal - GTX120705 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-ADC antibody [N2C2], Internal used in Western blot. GTX120705

ADC antibody, Internal - GTX45774 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-ADC antibody, Internal used in Western blot. GTX45774

ADC antibody - orb13407 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
Line graph illustrates about the Ag-Ab reactions using different concentrations of antigen and serial dilutions of ADC antibody

ADC antibody - 70R-15090 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ADC antibody - 70R-3996 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

ADC antibody (biotin) - 60R-1111 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ADC antibody (HRP) - 60R-1109 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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