| Gene Symbol |
AZIN2
|
| Entrez Gene |
113451
|
| Alt Symbol |
ADC, AZI2, AZIB1, ODC-p, ODC1L, ODCp
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
antizyme inhibitor 2
|
| Other Description |
ODC antizyme inhibitor-2|ODC-like protein|ODC-paralogue|arginine decarboxylase|ornithine decarboxylase like|ornithine decarboxylase paralog|ornithine decarboxylase-like protein|ornithine decarboxylase-paralog
|
| Swissprots |
Q5TIF5 Q96MD9 Q8TF56 Q5TIF4 Q96L57 Q96L55 D3DPQ9 Q96L54 Q96A70 Q96L56 Q5TIF6 B2RDU5
|
| Accessions |
CAD48798 EAX07469 EAX07470 EAX07471 EAX07472 EAX07473 EAX07474 EAX07475 EAX07476 EAX07477 EAX07478 EAX07479 EAX07480 EAX07481 EAX07482 Q96A70 AB075825 BAB85531 AK057051 BAB71356 AK095127 BAC04489 AK122697 BAG53674 AK315677 BAG38042 AL832640 AW450278 AY050634 AAL08049 AY050635 AAL08050 AY050636 AAL08051 AY050637 AAL08052 AY050638 AAL08053 AY325129 AAQ62560 BC010449 AAH10449 BC028128 AAH28128 DB456925 DQ892054 ABM82980 DQ895248 ABM86174 XM_005270404 XP_005270461 XM_005270406 XP_005270463 XM_005270407 XP_005270464 XM_006710311 XP_006710374 XM_006710312 XP_006710375 XM_011540557 XP_011538859 XM_011540558 XP_011538860 XM_011540559 XP_011538861 XM_011540560 XP_011538862 XM_011540561 XP_011538863 XM_011540562 XP_011538864 XM_011540563 XP_011538865 XM_011540564 XP_011538866 XM_011540565 XP_011538867 XM_011540566 XP_011538868 XR_946531 NM_001293562 NP_001280491 NM_001301823 NP_001288752 NM_001301824 NP_001288753 NM_001301825 NP_001288754 NM_001301826 NP_001288755 NM_052998 NP_443724 NR_126031
|
| Function |
Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728). {ECO:0000269|PubMed:14738999, ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:20188728}.
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Membrane {ECO:0000250}. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme-dependent manner. Localizes with vesicle- associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. {ECO:0
|
| Tissue Specificity |
Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis. {ECO:0000269|PubMed:11587527, ECO:0000269|PubMed:14738999, ECO:0000269|PubMed:19718454, ECO:0000269|PubMed:19756694, ECO:0000269|PubMed:19832840}.
|
| Top Pathways |
Arginine and proline metabolism
|