USP1

Gene Symbol	USP1
Entrez Gene	7398
Alt Symbol	UBP
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 1
Other Description	deubiquitinating enzyme 1|hUBP|ubiquitin carboxyl terminal hydrolase 1|ubiquitin carboxyl-terminal hydrolase 1|ubiquitin specific processing protease 1|ubiquitin specific protease 1|ubiquitin thioesterase 1|ubiquitin thiolesterase 1|ubiquitin-specific-processing protease 1
Swissprots	A0PJ95 Q05BX7 Q9UFR0 Q59H66 D3DQ57 O94782 Q9UNJ3
Accessions	EAX06585 EAX06586 O94782 AB014458 BAA34703 AB208893 BAD92130 AF117386 AAD11441 AK096788 AK312423 BAG35333 AL117503 CAB55967 AL117575 CAB55999 AL599240 AM392756 CAL37634 BC011881 BC018745 AAH18745 BC023216 BC032364 AAH32364 BC040140 BC050525 AAH50525 BI463072 BQ018843 BQ186837 NM_001017415 NP_001017415 NM_001017416 NP_001017416 NM_003368 NP_003359
Function	Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15694335}.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human USP1 + UAF1 full length protein - ab188739 from Abcam Category Protein Prices $792.00 Sizes 50 µg Source Baculovirus infected Sf21 cells Species Human

Active human USP1 (mutated G670 A + G671 A) full length protein - ab188718 from Abcam Category Protein Prices $572.00 Sizes 50 µg Source Baculovirus infected Sf21 cells Species Human

Human USP1 full length protein - ab132351 from Abcam Category Protein Source Wheat germ Species Human

Human USP1 peptide - ab28510 from Abcam Category Peptide

USP1 Antibody Blocking Peptide - LS-E4543 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP1 Antibody Blocking Peptide - LS-E21694 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP1 Antibody Blocking Peptide - LS-E6874 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP1 Recombinant Protein - H00007398-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

USP1/UAF1 Complex Peptide - P0914 from Novus Biologicals Category Peptide Species Human

USP1-Antibody-C-term-Blocking-Peptide - BP16884b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP1-Antibody-C-term-Blocking-Peptide - BP2130b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-USP1, CF - E-564-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains substitutions at G670A & G671A and a C-terminal 6-His tag

Recombinant Human His6-USP1/His6-UAF1 Complex, CF - E-568-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains a C-terminal 6-His tag

USP1 Blocking Peptide - 33R-8409 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP1 - H00007398-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP1 - H00007398-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

USP1 fusion protein - Ag5686 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

USP1 fusion protein - Ag5904 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human USP1, MYC/DDK-tagged - USP1-955H from Creative Biomart Category Protein Source HEK293 Cells

Recombinant Human USP1, GST-tagged - USP1-3614H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human USP1/UAF1, His-tagged - USP1-161H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human USP1, His-tagged - USP1-1066H from Creative Biomart Category Protein Source Baculovirus Sf21 Insect Cells Species Human

Recombinant Human USP1&WDR48, His-tagged - USP1&WDR48-1067H from Creative Biomart Category Protein Source Baculovirus Sf21 Insect Cells Species Human

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 1(USP1) - CSB-YP025695HU CSB-EP025695HU CSB-BP025695HU CSB-MP025695HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human His6-USP1/His6-UAF1 Complex Protein, CF - E-568 from R&D Systems Category Protein Prices $385.00 Sizes 50 µg Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Contains a C-terminal 6-His tag Species Human

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