NPAT

Gene Symbol NPAT
Entrez Gene 4863
Alt Symbol E14, E14/NPAT, p220
Species Human
Gene Type protein-coding
Description nuclear protein, ataxia-telangiectasia locus
Other Description E14|nuclear protein of the ATM locus|nuclear protein of the ataxia telangiectasia mutated locus|protein NPAT
Swissprots A8K1V5 Q8IWE9 Q86W55 A8K6M2 Q13632 Q14207 Q14967 Q16580
Accessions AAB65828 BAA21367 EAW67106 EAW67107 Q14207 AK290020 BAF82709 AK291687 BAF84376 AK301256 BAG62823 BC040356 AAH40356 BC050561 AAH50561 BC094769 BC136270 AAI36271 D83243 BAA11861 DA338219 U58852 AAB02735 X97186 CAA65824 XM_011542854 XP_011541156 XM_011542855 XP_011541157 NM_002519 NP_002510
Function Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.
Subcellular Location Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:8743993, ECO:0000269|PubMed:8923007}.

NPAT CRISPR/Cas9 KO Plasmid (h) - sc-404086 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPAT HDR Plasmid (h) - sc-404086-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPAT Double Nickase Plasmid (h) - sc-404086-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPAT Double Nickase Plasmid (h2) - sc-404086-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPAT CRISPR Activation Plasmid (h) - sc-404086-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPAT CRISPR Activation Plasmid (h2) - sc-404086-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPAT Lentiviral Activation Particles (h) - sc-404086-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPAT Lentiviral Activation Particles (h2) - sc-404086-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPAT siRNA (h) - sc-44351 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NPAT shRNA Plasmid (h) - sc-44351-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NPAT shRNA (h) Lentiviral Particles - sc-44351-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU054561 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15438 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15438 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09829 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09829

NPAT siRNA (Human) - CRH3234 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NPAT (NM_002519.2) - SHH354052 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NPAT(NM_002519.2) - SHR017394 from Creative biogene

Category siRNA
Species Reactivities Human

Human NPAT siRNA - orb263736 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NPAT shRNA Plasmid (Human) - CHH3234 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NPAT miRNA 3'UTR clone - MiUTR1H-06869 from Creative biogene

Species Reactivities Human
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