NPAT

Gene Symbol	NPAT
Entrez Gene	4863
Alt Symbol	E14, E14/NPAT, p220
Species	Human
Gene Type	protein-coding
Description	nuclear protein, ataxia-telangiectasia locus
Other Description	E14\|nuclear protein of the ATM locus\|nuclear protein of the ataxia telangiectasia mutated locus\|protein NPAT
Swissprots	A8K1V5 Q8IWE9 Q86W55 A8K6M2 Q13632 Q14207 Q14967 Q16580
Accessions	AAB65828 BAA21367 EAW67106 EAW67107 Q14207 AK290020 BAF82709 AK291687 BAF84376 AK301256 BAG62823 BC040356 AAH40356 BC050561 AAH50561 BC094769 BC136270 AAI36271 D83243 BAA11861 DA338219 U58852 AAB02735 X97186 CAA65824 XM_011542854 XP_011541156 XM_011542855 XP_011541157 NM_002519 NP_002510
Function	Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269\|PubMed:10995386, ECO:0000269\|PubMed:10995387, ECO:0000269\|PubMed:12665581, ECO:0000269\|PubMed:12724424, ECO:0000269\|PubMed:14585971, ECO:0000269\|PubMed:14612403, ECO:0000269\|PubMed:15555599, ECO:0000269\|PubMed:15988025, ECO:0000269\|PubMed:16131487, ECO:0000269\|PubMed:17163457, ECO:0000269\|PubMed:17826007, ECO:0000269\|PubMed:17967892, ECO:0000269\|PubMed:17974976, ECO:0000269\|PubMed:9472014}.
Subcellular Location	Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269\|PubMed:8743993, ECO:0000269\|PubMed:8923007}.

NPAT (M-300) - sc-67008 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

NPAT (H-300) - sc-67007 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

NPAT (H-300): sc-67007. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing nuclear staining of cells in non-germinal centers.

NPAT (C-19) - sc-32359 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

NPAT (C-19): sc-32359. Western blot analysis of NPAT expression in mouse testis tissue extract.

NPAT (27) - sc-136007 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

NPAT (27): sc-136007. Western blot analysis of NPAT expression in Jurkat whole cell lysate.

Anti-NPAT antibody - ab99436 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue labelling NPAT with ab99436 at 1/1000 (1µg/ml). Detection: DAB.

Anti-NPAT antibody [2648C6a] - ab70595 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2648C6a

Anti-NPAT antibody [2648C6a] (ab70595) + immunising recombinant fragment

Anti-NPAT Antibody (clone 2648C6a) - LS-C184637 from LifeSpan Bioscience

Prices	$335.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	2648C6a

Anti-NPAT Antibody (aa700-750) - LS-C289483 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human NPAT by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-NPAT used at a dilution of 1:1000 (1 Detection: DAB.

Anti-NPAT Antibody (aa1377-1427) - LS-C289482 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NPAT Antibody (clone 2648C6a) - LS-C342666 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2648C6a

Left : Western blot analysis of immunized recombinant protein, using anti-NPAT monoclonal antibody. Right : CBB staining of immunized recombinant protein.

Anti-NPAT Antibody - LS-C73775 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

NPAT antibody - 10R-1602 from Fitzgerald

Prices	$190.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	2648C6a

EIF4G1 antibody - 70R-4875 from Fitzgerald

Prices	$345.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Mouse Anti-Human NPAT - JI-04-00653 from RayBiotech

Host	Mouse

Anti-Phospho-EIF4G1-S1232, Polyclonal Antibody - 25-AP0279 from ARP American Research Products

Prices	$279.00, $549.00
Sizes	50 µg, 200 µg
Host	Rabbit
Clonality	Polyclonal

NPAT, Monoclonal Antibody - MBS120423 from MyBioSource

Prices	$345.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2648C6a

Nuclear Protein, Ataxia-telangiectasia Locus, Monoclonal Antibody - MBS601789 from MyBioSource

Prices	$365.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	8J134

EIF4G1 Polyclonal Antibody - EAP2475 from Elabscience

Prices	$296.00, $485.00
Sizes	120 μl, 200 μl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using EIF4G1 antibody.

EIF4G1 (phospho-Ser1232) Polyclonal Antibody - ESAP12213 from Elabscience

Prices	$296.00, $485.00
Sizes	120 μl, 200 μl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of HT29 cells untreated or treated with Anisomycin , using EIF4G1 (phospho-Ser1232) Polyclonal Antibody at dilution of 1:500

EIF4G1 Polyclonal Antibody - ESAP13456 from Elabscience

Prices	$296.00, $485.00
Sizes	120 μl, 200 μl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of Human thyroid cancer using EIF4G1 Polyclonal Antibody at dilution of 1:25

EIF4G1 Polyclonal Antibody - ESAP16765 from Elabscience

Prices	$296.00, $485.00
Sizes	120 μl, 200 μl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of Lovo and 293T cell, using EIF4G1 Polyclonal Antibody at dilution of 1:450

NPAT Antibody - A302-771A from Bethyl Labs

Prices	$99.00, $339.00
Sizes	10 µl (1 mg/ml), 100 µl (1 mg/ml)
Host	Rabbit
Clonality	Polyclonal

NPAT Antibody - A302-772A from Bethyl Labs

Prices	$99.00, $229.00, $339.00
Sizes	20 µl (2 blots), 100 µl (10 blots), 100 µl (1 mg/ml)
Host	Rabbit
Clonality	Polyclonal

NPAT Antibody AbVantage™ Pack - A311-016A from Bethyl Labs

Prices	$472.00
Sizes	1 pack
Host	Rabbit
Clonality	Polyclonal

Anti-Human NPAT - BMR00653 from Iwai North America Inc.

Prices	$300.00
Sizes	100 µg/ml (1ml)
Clonality	Monoclonal
Clone	2648C6a

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