| Gene Symbol |
NPAT
|
| Entrez Gene |
4863
|
| Alt Symbol |
E14, E14/NPAT, p220
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear protein, ataxia-telangiectasia locus
|
| Other Description |
E14|nuclear protein of the ATM locus|nuclear protein of the ataxia telangiectasia mutated locus|protein NPAT
|
| Swissprots |
A8K1V5 Q8IWE9 Q86W55 A8K6M2 Q13632 Q14207 Q14967 Q16580
|
| Accessions |
AAB65828 BAA21367 EAW67106 EAW67107 Q14207 AK290020 BAF82709 AK291687 BAF84376 AK301256 BAG62823 BC040356 AAH40356 BC050561 AAH50561 BC094769 BC136270 AAI36271 D83243 BAA11861 DA338219 U58852 AAB02735 X97186 CAA65824 XM_011542854 XP_011541156 XM_011542855 XP_011541157 NM_002519 NP_002510
|
| Function |
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.
|
| Subcellular Location |
Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:8743993, ECO:0000269|PubMed:8923007}.
|