Gene Symbol | PLCB4 |
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Entrez Gene | 5332 |
Alt Symbol | ARCND2, PI-PLC |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase C, beta 4 |
Other Description | 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4|PLC-beta-4|dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))|inositoltrisphosphohydrolase|monophosphatidylinositol phosphodiesterase|phosphoinositidase C|phosphoinositide phospholipase C-beta-4|triphosphoinositide phosphodiesterase |
Swissprots | Q9UJQ2 Q5JYT0 Q15147 Q9BQW5 Q9BQW6 Q17R56 B7ZLK6 Q5JYT3 Q9BQW8 E2QRH8 Q5JYT4 Q5JYS9 Q5JYS8 |
Accessions | EAX10364 EAX10365 EAX10366 EAX10367 EAX10368 EAX10369 EAX10370 Q15147 AK025027 AK054754 AK057634 AK122699 AK307482 AK307837 AL117633 AL844332 BC117458 AAI17459 BC143868 AAI43869 BG220268 BI439140 BX648680 DB270238 DN913865 DR761451 L41349 AAB02027 XM_005260724 XP_005260781 XM_005260728 XP_005260785 XM_006723568 XP_006723631 XM_006723569 XP_006723632 XM_011529251 XP_011527553 XM_011529252 XP_011527554 XM_011529253 XP_011527555 XM_011529254 XP_011527556 NM_000933 NP_000924 NM_001172646 NP_001166117 NM_182797 NP_877949 |
Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. |
Tissue Specificity | Preferentially expressed in the retina. |
Top Pathways | Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Estrogen signaling pathway, Inflammatory mediator regulation of TRP channels |
PLC β4 CRISPR/Cas9 KO Plasmid (h) - sc-418025 from Santa Cruz Biotechnology
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PLC β4 HDR Plasmid (h) - sc-418025-HDR from Santa Cruz Biotechnology
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PLC β4 Double Nickase Plasmid (h) - sc-418025-NIC from Santa Cruz Biotechnology
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PLC β4 Double Nickase Plasmid (h2) - sc-418025-NIC-2 from Santa Cruz Biotechnology
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PLC β4 CRISPR Activation Plasmid (h) - sc-418025-ACT from Santa Cruz Biotechnology
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PLC β4 CRISPR Activation Plasmid (h2) - sc-418025-ACT-2 from Santa Cruz Biotechnology
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PLC β4 Lentiviral Activation Particles (h) - sc-418025-LAC from Santa Cruz Biotechnology
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PLC β4 Lentiviral Activation Particles (h2) - sc-418025-LAC-2 from Santa Cruz Biotechnology
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PLC β4 siRNA (h) - sc-36274 from Santa Cruz Biotechnology
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PLC β4 shRNA Plasmid (h) - sc-36274-SH from Santa Cruz Biotechnology
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PLC β4 shRNA (h) Lentiviral Particles - sc-36274-V from Santa Cruz Biotechnology
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PLC-beta 4 RNAi - H00005332-R01 from Novus Biologicals
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MISSION® esiRNA - EHU087781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16923 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16923 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10609 from Sigma-Aldrich
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PLCB4 siRNA (Human) - CRH3572 from Cohesion Biosciences
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PLC-beta 4 RNAi - H00005332-R02 from Novus Biologicals
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shRNA set against Human Plcb4 (NM_000933.3) - SHH377144 from Creative biogene
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PLCB4 shRNA Plasmid (Human) - CHH3572 from Cohesion Biosciences
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PLCB4 miRNA 3'UTR clone - MiUTR3H-03641 from Creative biogene
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PLCB4 miRNA 3'UTR clone - MiUTR3H-03642 from Creative biogene
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