ARFGAP1

Gene Symbol	ARFGAP1
Entrez Gene	55738
Alt Symbol	ARF1GAP, HRIHFB2281
Species	Human
Gene Type	protein-coding
Description	ADP-ribosylation factor GTPase activating protein 1
Other Description	ADP-ribosylation factor GTPase-activating protein 1\|ARF1-directed GTPase-activating protein
Swissprots	Q9UIL0 E7EV62 B7Z3U0 B7Z8H8 B7ZBI3 E1P5I9 Q9NSU3 Q6PK71 Q96KC4 Q8N6T3 Q96T02 Q9NVF6
Accessions	EAW75290 EAW75291 EAW75292 EAW75293 EAW75294 EAW75295 EAW75296 Q8N6T3 AA565406 AB015340 BAA88117 AK001629 BAA91796 AK027268 BAB55009 AK027441 BAB55113 AK095048 AK123367 AK123873 AK223427 BAD97147 AK296351 BAH12326 AK303454 BAH13964 AK308161 AL137744 CAB70901 AY927573 BC000786 AAH00786 BC006085 AAH06085 BC011876 AAH11876 BC028233 AAH28233 BC127893 BQ717837 DC300118 DC404137 HQ447319 ADQ31806 XM_006723823 XP_006723886 XM_011528901 XP_011527203 XM_011528902 XP_011527204 XR_936567 XR_936568 XR_936569 XR_936570 XR_936571 XR_936572 XR_936574 XR_936575 XR_936576 NM_001281482 NP_001268411 NM_001281483 NP_001268412 NM_001281484 NP_001268413 NM_018209 NP_060679 NM_175609 NP_783202 NR_104022 NR_104023
Function	GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associates with the Golgi complex. {ECO:0000250}.
Top Pathways	Endocytosis

ARFGAP1 (D4C2M) Rabbit mAb - 14608 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D4C2M

Western blot analysis of extracts from various cell lines and tissues using ARFGAP1 (D4C2M) Rabbit mAb.

ARFGAP1 (D9A4V) Rabbit mAb - 14522 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D9A4V

Western blot analysis of extracts from various tissues and cell lines using ARFGAP1 (D9A4V) Rabbit mAb.

ARFGAP1 (H-300) - sc-98714 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

ARFGAP1 (H-300): sc-98714. Western blot analysis of ARFGAP1 expression in non-transfected: sc-110760 (A) and human ARFGAP1 transfected: sc-114757 (B) 293 whole cell lysates.

ARFGAP1 (C-4) - sc-271303 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

ARFGAP1 (C-4): sc-271303. Western blot analysis of ARFGAP1 expression in ZR-75-1 whole cell lysate.

ARFGAP1 (S-17) - sc-70015 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

ARFGAP1 (S-17): sc-70015. Western blot analysis of ARFGAP1 expression in non-transfected: sc-110760 (A) and human ARFGAP1 transfected: sc-114757 (B) 293 whole cell lysates and mouse brain tissue extract (C).

ARFGAP1 (N-14) - sc-70014 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-ARFGAP1 antibody - ab140085 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin embedded Human breast carcinoma tissue labelling ARFGAP1 with ab140085 at a dilution of 1/100

Anti-ARFGAP1 antibody [1H6] - ab124388 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1H6

All lanes : Anti-ARFGAP1 antibody [1H6] (ab124388) at 1/500 dilutionLane 1 : HEK293T cell lysate, transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate, transfected with pCMV6-ENTRY ARFGAP1 cDNALysates/proteins at 5 µg per lane.

Anti-ARFGAP1 antibody [2C10] - ab118161 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2C10

All lanes : Anti-ARFGAP1 antibody [2C10] (ab118161) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY ARFGAP1Lysates/proteins at 5 µg per lane.

Anti-ARFGAP1 antibody [EPR13650] - ab183746 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR13650

All lanes : Anti-ARFGAP1 antibody [EPR13650] (ab183746) at 1/5000 dilutionLane 1 : Human fetal brain lysateLane 2 : HepG2 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-rabbit IgG, (H+L), peroxidase conjugate at 1/1000 dilution

Anti-ARFGAP1 antibody - C-terminal - ab71759 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-ARFGAP1 antibody - C-terminal (ab71759) at 1/100 dilutionLane 1 : rat recombinant ARFGAP1 at 0.03 µgLane 2 : rat recombinant ARFGAP1 at 0.01 µgLane 3 : rat recombinant ARFGAP1 at 0.003 µg

Anti-ARFGAP1 Antibody (clone 1F6) - LS-C172786 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1F6

IHC of paraffin-embedded Human lymphoma tissue using anti-ARFGAP1 mouse monoclonal antibody.

Anti-ARFGAP1 Antibody (clone 1H6) - LS-C172746 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1H6

Anti-ARFGAP1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ARFGAP1.

Anti-ARFGAP1 Antibody (clone 2C6) - LS-C172785 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2C6

Anti-ARFGAP1 Antibody (clone 2C5) - LS-C172811 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2C5

Anti-ARFGAP1 Antibody (clone 1H4) - LS-C172787 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1H4

Anti-ARFGAP1 Antibody (C-Terminus) - LS-C24099 from LifeSpan Bioscience

Prices	$465.00
Sizes	250 µg
Host	Sheep
Clonality	Polyclonal

Anti-ARFGAP1 Antibody (aa123-139) - LS-C148568 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of ArfGAP1 using 1) preimmune sera at 1:5000 in human heart and protein A purified LS-C148568 in 2) human heart, 3) mouse heart and 4) rat heart at 2.0 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-ARFGAP1 Antibody (aa151-200) - LS-C117137 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

ARFGAP1 antibody LS-C117137 Western blot of Transfected 293T cell lysate.

Anti-ARFGAP1 Antibody (aa287-336) - LS-C135425 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

ARFGAP1 antibody LS-C135425 Western blot of Transfected 293T cell lysate.

Anti-ARFGAP1 Antibody (aa377-406, AP) - LS-C221459 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ARFGAP1 Antibody (aa377-406) - LS-C99653 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-ARFGAP1 Antibody (aa377-406, APC) - LS-C221460 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ARFGAP1 Antibody (aa377-406, FITC) - LS-C221461 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ARFGAP1 Antibody (aa377-406, Biotin) - LS-C221462 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

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