Gene Symbol | GRN |
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Entrez Gene | 2896 |
Alt Symbol | CLN11, GEP, GP88, PCDGF, PEPI, PGRN |
Species | Human |
Gene Type | protein-coding |
Description | granulin |
Other Description | PC cell-derived growth factor|acrogranin|granulin-epithelin|granulins|proepithelin|progranulin |
Swissprots | Q9UCH0 D3DX55 P28799 Q53HQ8 Q540U8 P23784 P23781 P23783 Q53Y88 P23782 Q9H8S1 Q9BWE7 |
Accessions | EAW51599 EAW51600 EAW51601 P28799 AF055008 AAC09359 AK000607 AK023348 BAB14535 AK222522 BAD96242 AK296090 BAG58844 AK303830 BAG64777 AY124489 AAM94026 BC000324 AAH00324 BC010577 AAH10577 BT006844 AAP35490 DC336362 M75161 AAA58617 X62320 CAA44196 XM_005257253 XP_005257310 NM_002087 NP_002078 NM_001012479 |
Function | Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. |
Subcellular Location | Secreted. |
Tissue Specificity | In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. |
acrogranin CRISPR/Cas9 KO Plasmid (h) - sc-401924 from Santa Cruz Biotechnology
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acrogranin HDR Plasmid (h) - sc-401924-HDR from Santa Cruz Biotechnology
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acrogranin Double Nickase Plasmid (h) - sc-401924-NIC from Santa Cruz Biotechnology
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acrogranin Double Nickase Plasmid (h2) - sc-401924-NIC-2 from Santa Cruz Biotechnology
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acrogranin CRISPR Activation Plasmid (h) - sc-401924-ACT from Santa Cruz Biotechnology
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acrogranin CRISPR Activation Plasmid (h2) - sc-401924-ACT-2 from Santa Cruz Biotechnology
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acrogranin Lentiviral Activation Particles (h) - sc-401924-LAC from Santa Cruz Biotechnology
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acrogranin Lentiviral Activation Particles (h2) - sc-401924-LAC-2 from Santa Cruz Biotechnology
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acrogranin siRNA (h) - sc-39261 from Santa Cruz Biotechnology
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acrogranin shRNA Plasmid (h) - sc-39261-SH from Santa Cruz Biotechnology
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acrogranin shRNA (h) Lentiviral Particles - sc-39261-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU066601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2047 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2047 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01723 from Sigma-Aldrich
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GRN siRNA (Human) - CRH1950 from Cohesion Biosciences
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Granulin RNAi - H00002896-R01 from Novus Biologicals
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GRN - MBS8240327 from MyBioSource
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shRNA set against Human GRN (NM_002087.2) - SHH308182 from Creative biogene
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Human GRN siRNA - orb262452 from Biorbyt
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GRN shRNA Plasmid (Human) - CHH1950 from Cohesion Biosciences
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GRN miRNA 3'UTR clone - MiUTR1H-04293 from Creative biogene
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