Gene Symbol | GRN |
---|---|
Entrez Gene | 2896 |
Alt Symbol | CLN11, GEP, GP88, PCDGF, PEPI, PGRN |
Species | Human |
Gene Type | protein-coding |
Description | granulin |
Other Description | PC cell-derived growth factor|acrogranin|granulin-epithelin|granulins|proepithelin|progranulin |
Swissprots | Q9UCH0 D3DX55 P28799 Q53HQ8 Q540U8 P23784 P23781 P23783 Q53Y88 P23782 Q9H8S1 Q9BWE7 |
Accessions | EAW51599 EAW51600 EAW51601 P28799 AF055008 AAC09359 AK000607 AK023348 BAB14535 AK222522 BAD96242 AK296090 BAG58844 AK303830 BAG64777 AY124489 AAM94026 BC000324 AAH00324 BC010577 AAH10577 BT006844 AAP35490 DC336362 M75161 AAA58617 X62320 CAA44196 XM_005257253 XP_005257310 NM_002087 NP_002078 NM_001012479 |
Function | Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. |
Subcellular Location | Secreted. |
Tissue Specificity | In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. |