| Gene Symbol |
EIF3F
|
| Entrez Gene |
8665
|
| Alt Symbol |
EIF3S5, eIF3-p47
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 3, subunit F
|
| Other Description |
deubiquitinating enzyme eIF3f|eIF-3-epsilon|eIF3-epsilon|eukaryotic translation initiation factor 3 subunit F|eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD)|eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa
|
| Swissprots |
A8K0S2 Q6IB45 Q8N978 O00303
|
| Accessions |
EAW68637 O00303 AK027739 AK093511 BAG52733 AK095574 BAC04577 AK289637 BAF82326 AK291354 BAF84043 AK293826 BAG57230 AK297621 BAG59997 BC000490 AAH00490 BC073753 BT006894 AAP35540 CB141463 CD050033 CR456959 CAG33240 DQ890766 ABM81692 HQ448263 ADQ32743 U94855 AAD03467 NM_003754 NP_003745
|
| Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255|HAMAP- Rule:MF_03005, ECO:0000269|PubMed:21124883}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
|
| Top Pathways |
RNA transport
|