INO80

Gene Symbol INO80
Entrez Gene 54617
Alt Symbol INO80A, INOC1, hINO80
Species Human
Gene Type protein-coding
Description INO80 complex subunit
Other Description DNA helicase INO80|INO80 complex subunit A|INO80 homolog|homolog of yeast INO80|putative DNA helicase INO80 complex homolog 1
Swissprots A6H8X4 Q9ULG1 Q9NTG6
Accessions EAW92468 EAW92469 EAW92470 EAW92471 Q9ULG1 AB033085 BAA86573 AK002176 BAA92122 AK024777 BAB14997 AK026050 AK057582 AK290371 BAF83060 AL137280 CAB70675 BC012578 BC046115 BC057299 BC068054 BC105993 BC144681 BC146785 AAI46786 BX350023 CB155560 XM_011521685 XP_011519987 XM_011521686 XP_011519988 NM_017553 NP_060023 NR_104038 NM_032196
Function DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00746, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20971067}. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner.
Tissue Specificity According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas. {ECO:0000269|PubMed:10574462, ECO:0000269|PubMed:16298340}.

INOC1 CRISPR/Cas9 KO Plasmid (h) - sc-407798 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INOC1 HDR Plasmid (h) - sc-407798-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INOC1 Double Nickase Plasmid (h) - sc-407798-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INOC1 Double Nickase Plasmid (h2) - sc-407798-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INOC1 CRISPR Activation Plasmid (h) - sc-407798-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INOC1 CRISPR Activation Plasmid (h2) - sc-407798-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INOC1 Lentiviral Activation Particles (h) - sc-407798-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INOC1 Lentiviral Activation Particles (h2) - sc-407798-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INOC1 siRNA (h) - sc-90293 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INOC1 shRNA Plasmid (h) - sc-90293-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INOC1 shRNA (h) Lentiviral Particles - sc-90293-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INO80 RNAi - H00054617-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

INO80 RNAi - H00054617-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU069661 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10683 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10683 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08853 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08853

INO80 siRNA (Human) - CRJ0154 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

INO80 - MBS827901 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human INO80 (NM_017553.1) - SHH319601 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human INOC1(NM_017553.1) - SHL178308 from Creative biogene

Category siRNA
Species Reactivities Human

Human INO80 siRNA - orb270655 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

INO80 shRNA Plasmid (Human) - CHJ0154 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

INO80 miRNA 3'UTR clone - MiUTR1H-04953 from Creative biogene

Species Reactivities Human
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