INO80

Gene Symbol INO80
Entrez Gene 54617
Alt Symbol INO80A, INOC1, hINO80
Species Human
Gene Type protein-coding
Description INO80 complex subunit
Other Description DNA helicase INO80|INO80 complex subunit A|INO80 homolog|homolog of yeast INO80|putative DNA helicase INO80 complex homolog 1
Swissprots A6H8X4 Q9ULG1 Q9NTG6
Accessions EAW92468 EAW92469 EAW92470 EAW92471 Q9ULG1 AB033085 BAA86573 AK002176 BAA92122 AK024777 BAB14997 AK026050 AK057582 AK290371 BAF83060 AL137280 CAB70675 BC012578 BC046115 BC057299 BC068054 BC105993 BC144681 BC146785 AAI46786 BX350023 CB155560 XM_011521685 XP_011519987 XM_011521686 XP_011519988 NM_017553 NP_060023 NR_104038 NM_032196
Function DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00746, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20971067}. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner.
Tissue Specificity According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas. {ECO:0000269|PubMed:10574462, ECO:0000269|PubMed:16298340}.

INOC1 (H-300) - sc-134689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

INOC1 (E-16) - sc-164673 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-INO80 antibody - ab135035 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-INO80 antibody (ab135035) at 1/1000 dilution + Mouse thymus cell extract

Anti-INO80 Antibody (aa438-450) - LS-C108916 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-INO80 Antibody (aa1506-1556) - LS-C290055 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-INO80 Antibody (aa1400-1450) IHC-plus™ - LS-B11393 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-INO80 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11393 concentration 5 ug/ml.

INO80 Antibody - NBP1-78759 from Novus Biologicals

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: INO80 Antibody [NBP1-78759] - Whole cell lysate from HeLa (15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg) and Jurkat (J; 50 mcg) cells. Affinity purified rabbit anti-INO80 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. INO80 was also immunoprecipitated by rabbit anti-INO80 antibody NBP1-78758 which recognizes an upstream epitope.

INO80 Antibody - NBP1-78758 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: INO80 Antibody [NBP1-78758] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. AAffinity purified rabbit anti-INO80 antibody used for IP at 6 mcg/mg lysate. INO80 was also immunoprecipitated by rabbit anti-INO80 antibody NBP1-78759 which recognizes a downstream epitope.

INO80 Antibody - NBP1-46157 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

INO80-Antibody-internal-region - AF3046a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

INO80 antibody, Internal - GTX88243 from GeneTex

Prices $239.00
Sizes 100 μg
Host Goat
Clonality Polyclonal

INO80 antibody - orb67034 from Biorbyt

Prices $425.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell extracts from mouse thymus using INO80 antibody

INO80 Antibody (OAEB00608) - OAEB00608 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

INO80 antibody - 70R-17977 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti -INO80 (INO80 Homolog (S. cerevisiae)) - I7654-92 from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -INO80 (INO80 Homolog (S. cerevisiae)) (AP) - I7654-92-AP from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -INO80 (INO80 Homolog (S. cerevisiae)) (APC) - I7654-92-APC from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -INO80 (INO80 Homolog (S. cerevisiae)) (Biotin) - I7654-92-Biotin from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -INO80 (INO80 Homolog (S. cerevisiae)) (FITC) - I7654-92-FITC from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -INO80 (INO80 Homolog (S. cerevisiae)) (HRP) - I7654-92-HRP from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -INO80 (INO80 Homolog (S. cerevisiae)) (PE) - I7654-92-PE from USBiological Life Science

Host Goat
Clonality Polyclonal

INO80 / INOC1 antibody - 18810-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Mouse brain tissue were subjected to SDS PAGE followed by western blot with 18810-1-AP(INO80 antibody) at dilution of 1:500

INO80 / INOC1 antibody - 24819-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
HepG2 cells were subjected to SDS PAGE followed by western blot with 24819-1-AP( INO80 Antibody) at dilution of 1:600

Anti-INO80 Antibody - AC21-2025 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-INO80 Antibody (AMCA) - AC21-2025-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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