| Gene Symbol |
INO80
|
| Entrez Gene |
54617
|
| Alt Symbol |
INO80A, INOC1, hINO80
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
INO80 complex subunit
|
| Other Description |
DNA helicase INO80|INO80 complex subunit A|INO80 homolog|homolog of yeast INO80|putative DNA helicase INO80 complex homolog 1
|
| Swissprots |
A6H8X4 Q9ULG1 Q9NTG6
|
| Accessions |
EAW92468 EAW92469 EAW92470 EAW92471 Q9ULG1 AB033085 BAA86573 AK002176 BAA92122 AK024777 BAB14997 AK026050 AK057582 AK290371 BAF83060 AL137280 CAB70675 BC012578 BC046115 BC057299 BC068054 BC105993 BC144681 BC146785 AAI46786 BX350023 CB155560 XM_011521685 XP_011519987 XM_011521686 XP_011519988 NM_017553 NP_060023 NR_104038 NM_032196
|
| Function |
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00746, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20971067}. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner.
|
| Tissue Specificity |
According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas. {ECO:0000269|PubMed:10574462, ECO:0000269|PubMed:16298340}.
|