| Gene Symbol |
Srebf1
|
| Entrez Gene |
78968
|
| Alt Symbol |
ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
sterol regulatory element binding transcription factor 1
|
| Other Description |
adipocyte determination- and differentiation-dependent factor 1|sterol regulatory element-binding protein 1
|
| Swissprots |
Q99PI6 P56720 Q99PI7
|
| Accessions |
EDM04632 EDM04633 P56720 AF286469 AAG28733 AF286470 AAG28734 XM_008767879 XP_008766101 NM_001276707 NP_001263636 NM_001276708 NP_001263637
|
| Function |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (PubMed:7739539). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA- 3') and to SRE-1 (5'-ATCACCCCAC-3'). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:7739539}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
|
| Tissue Specificity |
Expressed predominantly in brown adipose tissue.
|
| Top Pathways |
Insulin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway
|