Srebf1

Gene Symbol	Srebf1
Entrez Gene	78968
Alt Symbol	ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1
Species	Rat
Gene Type	protein-coding
Description	sterol regulatory element binding transcription factor 1
Other Description	adipocyte determination- and differentiation-dependent factor 1\|sterol regulatory element-binding protein 1
Swissprots	Q99PI6 P56720 Q99PI7
Accessions	EDM04632 EDM04633 P56720 AF286469 AAG28733 AF286470 AAG28734 XM_008767879 XP_008766101 NM_001276707 NP_001263636 NM_001276708 NP_001263637
Function	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (PubMed:7739539). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA- 3') and to SRE-1 (5'-ATCACCCCAC-3'). {ECO:0000250\|UniProtKB:Q9WTN3, ECO:0000269\|PubMed:7739539}.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
Tissue Specificity	Expressed predominantly in brown adipose tissue.
Top Pathways	Insulin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

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