| Gene Symbol | Srebf1 |
|---|---|
| Entrez Gene | 78968 |
| Alt Symbol | ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | sterol regulatory element binding transcription factor 1 |
| Other Description | adipocyte determination- and differentiation-dependent factor 1|sterol regulatory element-binding protein 1 |
| Swissprots | Q99PI6 P56720 Q99PI7 |
| Accessions | EDM04632 EDM04633 P56720 AF286469 AAG28733 AF286470 AAG28734 XM_008767879 XP_008766101 NM_001276707 NP_001263636 NM_001276708 NP_001263637 |
| Function | Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (PubMed:7739539). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA- 3') and to SRE-1 (5'-ATCACCCCAC-3'). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:7739539}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. |
| Tissue Specificity | Expressed predominantly in brown adipose tissue. |
| Top Pathways | Insulin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
Alpha-adducin (ADD1), Rat, ELISA Kit - E02A1263 from ARP American Research Products
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Sterol regulatory element-binding protein 1A (SREBP-1A), Rat, ELISA Kit - CSB-E13121r from ARP American Research Products
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Sterol regulatory element-binding protein 1C (SREBP-1C), Rat, ELISA Kit - CSB-E17414r from ARP American Research Products
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sterol regulatory element binding transcription factor 1, ELISA Kit - MBS703466 from MyBioSource
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Rat sterol regulatory element-binding protein 1A(SREBP-1A) ELISA Kit - CSB-E13121r from Cusabio
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Rat Add1 ELISA Kit - E074693 from Biobool
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SREBF1 ELISA Kit (Rat) (OKEI00843) - OKEI00843 from Aviva Systems Biology
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Rat SREBP-1C ELISA Kit - orb410887 from Biorbyt
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