Gene Symbol | C1QL3 |
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Entrez Gene | 389941 |
Alt Symbol | C1QTNF13, C1ql, CTRP13, K100 |
Species | Human |
Gene Type | protein-coding |
Description | complement component 1, q subcomponent-like 3 |
Other Description | C1q and tumor necrosis factor-related protein 13|C1q/TNF-related protein 13|complement C1q-like protein 3 |
Swissprots | Q5VWW1 A0PJY5 A0PJY4 |
Accessions | CAI58841 EAW86225 Q5VWW1 AK094686 BC127716 AAI27717 BC127717 AAI27718 BC160038 AAI60038 NM_001010908 NP_001010908 |
Function | May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney. {ECO:0000269|PubMed:21378161}. |
C1qL3 CRISPR/Cas9 KO Plasmid (h) - sc-415847 from Santa Cruz Biotechnology
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C1qL3 HDR Plasmid (h) - sc-415847-HDR from Santa Cruz Biotechnology
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C1qL3 Double Nickase Plasmid (h) - sc-415847-NIC from Santa Cruz Biotechnology
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C1qL3 Double Nickase Plasmid (h2) - sc-415847-NIC-2 from Santa Cruz Biotechnology
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C1qL3 CRISPR Activation Plasmid (h) - sc-415847-ACT from Santa Cruz Biotechnology
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C1qL3 CRISPR Activation Plasmid (h2) - sc-415847-ACT-2 from Santa Cruz Biotechnology
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C1qL3 Lentiviral Activation Particles (h) - sc-415847-LAC from Santa Cruz Biotechnology
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C1qL3 Lentiviral Activation Particles (h2) - sc-415847-LAC-2 from Santa Cruz Biotechnology
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C1qL3 siRNA (h) - sc-105155 from Santa Cruz Biotechnology
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C1qL3 shRNA Plasmid (h) - sc-105155-SH from Santa Cruz Biotechnology
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C1qL3 shRNA (h) Lentiviral Particles - sc-105155-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU158971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4688 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4688 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06529 from Sigma-Aldrich
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C1QL3 siRNA (Human) - CRJ7918 from Cohesion Biosciences
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C1QL3 - MBS8238329 from MyBioSource
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shRNA set against Human C1ql3 (NM_001010908.1) - SHH250745 from Creative biogene
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shRNA set against Human C1QL3(NM_001010908.1) - SHG120745 from Creative biogene
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Human C1QL3 siRNA - orb278419 from Biorbyt
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C1QL3 shRNA Plasmid (Human) - CHJ7918 from Cohesion Biosciences
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C1QL3 miRNA 3'UTR clone - MiUTR1H-01288 from Creative biogene
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