| Gene Symbol |
C1QL3
|
| Entrez Gene |
389941
|
| Alt Symbol |
C1QTNF13, C1ql, CTRP13, K100
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
complement component 1, q subcomponent-like 3
|
| Other Description |
C1q and tumor necrosis factor-related protein 13|C1q/TNF-related protein 13|complement C1q-like protein 3
|
| Swissprots |
Q5VWW1 A0PJY5 A0PJY4
|
| Accessions |
CAI58841 EAW86225 Q5VWW1 AK094686 BC127716 AAI27717 BC127717 AAI27718 BC160038 AAI60038 NM_001010908 NP_001010908
|
| Function |
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney. {ECO:0000269|PubMed:21378161}.
|