CYP46A1

Gene Symbol CYP46A1
Entrez Gene 10858
Alt Symbol CP46, CYP46
Species Human
Gene Type protein-coding
Description cytochrome P450, family 46, subfamily A, polypeptide 1
Other Description CH24H|cholesterol 24-hydroxylase|cytochrome P450 46A1|cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Swissprots Q9Y6A2 E7EQG9 Q8N2B0 B4DHP8
Accessions EAW81678 Q9Y6A2 AB209749 BAD92986 AF094480 AAD41244 AK090886 BAC03539 AK295216 BAG58210 BC022539 AAH22539 XM_005267274 XP_005267331 XM_011536364 XP_011534666 XM_011536365 XP_011534667 NM_006668 NP_006659
Function Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. {ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Tissue Specificity Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.
Top Pathways Primary bile acid biosynthesis

CYP46 CRISPR/Cas9 KO Plasmid (h) - sc-405144 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP46 HDR Plasmid (h) - sc-405144-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP46 Double Nickase Plasmid (h) - sc-405144-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP46 Double Nickase Plasmid (h2) - sc-405144-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP46 CRISPR Activation Plasmid (h) - sc-405144-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP46 CRISPR Activation Plasmid (h2) - sc-405144-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP46 Lentiviral Activation Particles (h) - sc-405144-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP46 Lentiviral Activation Particles (h2) - sc-405144-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP46 siRNA (h) - sc-77075 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP46 shRNA Plasmid (h) - sc-77075-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP46 shRNA (h) Lentiviral Particles - sc-77075-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP46A1 RNAi - H00010858-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU130401 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6889 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6889 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CYP46A1 siRNA (Human) - CRH7394 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP46A1 - MBS8209741 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CYP46A1 (NM_006668.1) - SHH273533 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CYP46A1(NM_006668.1) - SHG207169 from Creative biogene

Category siRNA
Species Reactivities Human

Human CYP46A1 siRNA - orb267896 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP46A1 shRNA Plasmid (Human) - CHH7394 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CYP46A1 miRNA 3'UTR clone - MiUTR1H-02635 from Creative biogene

Species Reactivities Human
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