CYP46A1

Gene Symbol	CYP46A1
Entrez Gene	10858
Alt Symbol	CP46, CYP46
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 46, subfamily A, polypeptide 1
Other Description	CH24H|cholesterol 24-hydroxylase|cytochrome P450 46A1|cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Swissprots	Q9Y6A2 E7EQG9 Q8N2B0 B4DHP8
Accessions	EAW81678 Q9Y6A2 AB209749 BAD92986 AF094480 AAD41244 AK090886 BAC03539 AK295216 BAG58210 BC022539 AAH22539 XM_005267274 XP_005267331 XM_011536364 XP_011534666 XM_011536365 XP_011534667 NM_006668 NP_006659
Function	Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. {ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Tissue Specificity	Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.
Top Pathways	Primary bile acid biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CYP46 protein fragment - ab161176 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human CYP46A1 Protein - H00010858-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CYP46A1-Antibody-Center-Blocking-Peptide - BP8726c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CYP46A1-Antibody-N-term-Blocking-Peptide - BP8726a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CYP46A1 Blocking Peptide - 33R-10280 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CYP46A1 - H00010858-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CYP46A1 - H00010858-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CYP46A1 fusion protein - Ag16786 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CYP46A1 fusion protein - ag3116 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CYP46A1 protein, MYC/DDK-tagged - CYP46A1-258H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Human CYP46A1 protein, GST-tagged - CYP46A1-259H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human CYP46A1, His-tagged - CYP46A1-11786H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Cholesterol 24-hydroxylase(CYP46A1) - CSB-YP897584HU CSB-EP897584HU CSB-BP897584HU CSB-MP897584HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CYP46A1 - TP305446 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CYP46A1 Peptide, Human - M34GP03974H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cholesterol 24-hydroxylase (CYP46A1), Recombinant Protein - MBS1366880 from MyBioSource Category Protein Prices $1,285.00, $1,285.00, $1,505.00, $1,505.00, $2,110.00, $2,110.00, $2,575.00, $2,575.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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