PINK1

Gene Symbol	PINK1
Entrez Gene	65018
Alt Symbol	BRPK, PARK6
Species	Human
Gene Type	protein-coding
Description	PTEN induced putative kinase 1
Other Description	PTEN-induced putative kinase protein 1|protein kinase BRPK|serine/threonine-protein kinase PINK1, mitochondrial
Swissprots	Q8N6T9 Q9BXM7 Q96DE4 Q8NBU3
Accessions	CBX51399 EAW94934 EAW94935 Q9BXM7 AB053323 BAB55647 AF316873 AAK28062 AK075225 BAC11484 AK130746 BC009534 AAH09534 BC028215 AAH28215 DQ891033 ABM81959 DQ893330 ABM84256 DQ894212 ABM85138 DQ896646 ABM87645 NM_032409 NP_115785
Function	Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). {ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291}.
Subcellular Location	Mitochondrion outer membrane; Single-pass membrane protein {ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18687899, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23933751}. Cytoplasm, cytosol {ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600}. Note=Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol. {ECO:0000269|PubMed:19229105}.
Tissue Specificity	Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. {ECO:0000269|PubMed:11494141}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PINK1 peptide - ab30903 from Abcam Category Peptide Species Human

Human PINK1 protein fragment - ab116177 from Abcam Category Protein Source E. coli Species Human

PINK1 Antibody Blocking Peptide - LS-E3118 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PINK1 Antibody Blocking Peptide - LS-E8225 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PINK1 Antibody Blocking Peptide - LS-E8226 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PINK1 Antibody Blocking Peptide - LS-E23092 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PINK1 Antibody Blocking Peptide - LS-E26407 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PINK1 Blocking Peptide - NB100-493PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

PINK1 Blocking Peptide - BC100-494PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µl Species Human

Recombinant Human PINK1 Protein - NBP1-72481 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

Recombinant Human PINK1 Protein - H00065018-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Drosophila-PARK6-Antibody-C-term-Blocking-peptide - BP6415b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Drosophila

Drosophila-PARK6-Antibody-N-term-Blocking-Peptide - BP6415a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Drosophila

Park6PINK1-AntibodyC-term-Blocking-peptide - BP6406d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PINK1-PARK6-Antibody-Center-Blocking-peptide - BP6406b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PINK1-PARK6-Antibody-N-term-T133-Blocking-peptide - BP6406a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PINK1 blocking peptide - GTX88986-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Bovine AGE-BSA Biotinylated Protein, CF - BT4127 from R&D Systems Category Protein Prices $259.00 Sizes 250 µg Source Bovine serum-derived Advanced glycation end product (AGE) of bovine serum albumin (AGE-BSA) was prepared by incubating BSA and glucose under sterile conditions at 37 °C for 60 days and then biotinylated. Species Bovine

Human PINK1 protein - orb169032 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

PINK1 peptide - orb108483 from Biorbyt Category Peptide Prices $374.00 Sizes 50 μg

PINK1 Blocking Peptide - 33R-11003 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

PINK1 protein - 30R-2086 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human PINK1 Protein - abx068789 from Abbexa Category Protein Source E.coli Species Human

PINK1 Peptide - AC21-1246-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PINK1 (156-507) - AR50065PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

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