PINK1

Gene Symbol PINK1
Entrez Gene 65018
Alt Symbol BRPK, PARK6
Species Human
Gene Type protein-coding
Description PTEN induced putative kinase 1
Other Description PTEN-induced putative kinase protein 1|protein kinase BRPK|serine/threonine-protein kinase PINK1, mitochondrial
Swissprots Q8N6T9 Q9BXM7 Q96DE4 Q8NBU3
Accessions CBX51399 EAW94934 EAW94935 Q9BXM7 AB053323 BAB55647 AF316873 AAK28062 AK075225 BAC11484 AK130746 BC009534 AAH09534 BC028215 AAH28215 DQ891033 ABM81959 DQ893330 ABM84256 DQ894212 ABM85138 DQ896646 ABM87645 NM_032409 NP_115785
Function Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). {ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291}.
Subcellular Location Mitochondrion outer membrane; Single-pass membrane protein {ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18687899, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23933751}. Cytoplasm, cytosol {ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600}. Note=Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol. {ECO:0000269|PubMed:19229105}.
Tissue Specificity Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. {ECO:0000269|PubMed:11494141}.

PINK1-Over-expression-Lysate - LY10497a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PINK1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PINK1 gene

PINK1 overexpression lysate - LY410150 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

PINK1 Overexpression Lysate (Native) - NBP2-06032 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PINK1 Overexpression Lysate (Adult Normal) [NBP2-06032] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PINK1.

PINK1 Overexpression Lysate (Denatured) - H00065018-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Western Blot: PINK1 Overexpression Lysate (Denatured) [H00065018-T02] - Lane 1: PINK1 transfected lysate ( 62.70 KDa)Lane 2: Non-transfected lysate.

Panoply™ Human PINK1 Knockdown Stable Cell Line - CSC-DC011802 from Creative biogene

Category Cell Line
Species Human

Human PINK1 Knockout Cell Line-HEK293T - CSC-RT1473 from Creative biogene

Category Cell Line
Species Human

PINK1 KO Cell Lysate-HEK293T - CLKO-1323 from Creative biogene

Category Cell Lysate
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