PINK1

Gene Symbol PINK1
Entrez Gene 65018
Alt Symbol BRPK, PARK6
Species Human
Gene Type protein-coding
Description PTEN induced putative kinase 1
Other Description PTEN-induced putative kinase protein 1|protein kinase BRPK|serine/threonine-protein kinase PINK1, mitochondrial
Swissprots Q8N6T9 Q9BXM7 Q96DE4 Q8NBU3
Accessions CBX51399 EAW94934 EAW94935 Q9BXM7 AB053323 BAB55647 AF316873 AAK28062 AK075225 BAC11484 AK130746 BC009534 AAH09534 BC028215 AAH28215 DQ891033 ABM81959 DQ893330 ABM84256 DQ894212 ABM85138 DQ896646 ABM87645 NM_032409 NP_115785
Function Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). {ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291}.
Subcellular Location Mitochondrion outer membrane; Single-pass membrane protein {ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18687899, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:23933751}. Cytoplasm, cytosol {ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20798600}. Note=Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol. {ECO:0000269|PubMed:19229105}.
Tissue Specificity Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. {ECO:0000269|PubMed:11494141}.

PINK1 (D8G3) Rabbit mAb - 6946 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8G3
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a cDNA construct expressing full-length human PINK1 (hPINK1, +) using PINK1 (D8G3) Rabbit mAb.

PINK1 (N4/15.11) Mouse mAb - 5660 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone N4/15.11
Western blot analysis of extracts from COS-7 cells mock transfected (-) or transfected with human PINK1 (+) using PINK1 (N4/15.11) Mouse mAb.

PINK1 (H-300) - sc-33796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PINK1 (H-300): sc-33796. Western blot analysis of PINK1 expression in rat brain (A) and mouse brain (B) tissue extracts.

PINK1 (C-20) - sc-32584 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PINK1 (P-20) - sc-32583 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PINK1 (P-20): sc-32583. Western blot analysis of PINK1 expression in Hep G2 whole cell lysate.

Anti-PINK1 (mutated G309 D) antibody - ab169868 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PINK1 antibody - ab63950 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-PINK1 antibody (ab63950) at 1 µg/ml + Rat Testis lysate (35µg protein in RIPA buffer).

Anti-PINK1 antibody - ab33250 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINK1 antibody [38CT18.7] - ab75487 from Abcam

Prices $387.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 38CT18.7
Immunocytochemistry/Immunofluorescence analysis of PC-12 cells labelling PINK1 (green) with ab75487 at a dilution of 1/25. An Alexa Fluor® 488-conjugated goat anti-mouse IgG was used as the secondary antibody (1/400). Cytoplasmic actin was counterstained with Alexa Fluor® 555-conjugated with Phalloidin (red).

Anti-PINK1 antibody [38CT20.8.5] - ab117091 from Abcam

Prices $384.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 38CT20.8.5
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex tissue, staining PINK1 with ab117091 at 1/50. Antigen retrieval was performed by heat mediation in citrate buffer (pH 6).

Anti-PINK1 antibody [S4-15] - ab186303 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S4-15

Anti-PINK1 antibody [S4-15] (Biotin) - ab186315 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S4-15

Anti-PINK1 antibody [S4-15] (HRP) - ab186292 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S4-15

Anti-PINK1 Antibody (aa1-18) - LS-C3158 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (aa258-274) - LS-C40756 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (aa258-274) - LS-C9809 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (N-Terminus) - LS-C47094 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (C-Terminus) - LS-C47093 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (C-Terminus) - LS-C83398 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (aa175-250) - LS-C91643 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (N-Terminus) - LS-C91646 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody - LS-C124456 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PINK1 Antibody (N-Terminus, Biotin) - LS-C141175 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (N-Terminus, DY650) - LS-C141176 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PINK1 Antibody (N-Terminus, DY488) - LS-C141177 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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