Gene Symbol | PIR |
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Entrez Gene | 8544 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | pirin (iron-binding nuclear protein) |
Other Description | pirin|probable quercetin 2,3-dioxygenase PIR|probable quercetinase |
Swissprots | Q6FHD2 O00625 Q5U0G0 |
Accessions | CAD33303 EAW98886 EAW98887 EAW98888 O00625 AK309656 BC002517 AAH02517 BT019583 AAV38390 BT019584 AAV38391 CR541822 CAG46621 DA686501 DQ891941 ABM82867 DQ895128 ABM86054 DT217415 Y07867 CAA69194 Y07868 CAA69195 NM_001018109 NP_001018119 NM_003662 NP_003653 |
Function | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269|PubMed:17288615, ECO:0000269|PubMed:20010624, ECO:0000269|PubMed:20711196, ECO:0000269|PubMed:23716661}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. |
Tissue Specificity | Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}. |
pirin CRISPR/Cas9 KO Plasmid (h) - sc-404925 from Santa Cruz Biotechnology
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pirin HDR Plasmid (h) - sc-404925-HDR from Santa Cruz Biotechnology
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pirin Double Nickase Plasmid (h) - sc-404925-NIC from Santa Cruz Biotechnology
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pirin Double Nickase Plasmid (h2) - sc-404925-NIC-2 from Santa Cruz Biotechnology
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pirin CRISPR Activation Plasmid (h) - sc-404925-ACT from Santa Cruz Biotechnology
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pirin CRISPR Activation Plasmid (h2) - sc-404925-ACT-2 from Santa Cruz Biotechnology
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pirin Lentiviral Activation Particles (h) - sc-404925-LAC from Santa Cruz Biotechnology
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pirin Lentiviral Activation Particles (h2) - sc-404925-LAC-2 from Santa Cruz Biotechnology
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pirin siRNA (h) - sc-61359 from Santa Cruz Biotechnology
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pirin shRNA Plasmid (h) - sc-61359-SH from Santa Cruz Biotechnology
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pirin shRNA (h) Lentiviral Particles - sc-61359-V from Santa Cruz Biotechnology
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Pirin RNAi - H00008544-R01 from Novus Biologicals
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Pirin RNAi - H00008544-R02 from Novus Biologicals
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MISSION® esiRNA - EHU013891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16833 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16833 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01584 from Sigma-Aldrich
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PIR siRNA (Human) - CRH5615 from Cohesion Biosciences
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shRNA set against Human PIR (NM_003662.3) - SHH376084 from Creative biogene
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Human PIR siRNA - orb266117 from Biorbyt
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PIR shRNA Plasmid (Human) - CHH5615 from Cohesion Biosciences
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PIR miRNA 3'UTR clone - MiUTR3H-05865 from Creative biogene
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PIR miRNA 3'UTR clone - MiUTR3H-05866 from Creative biogene
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