PIR

Gene Symbol	PIR
Entrez Gene	8544
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	pirin (iron-binding nuclear protein)
Other Description	pirin\|probable quercetin 2,3-dioxygenase PIR\|probable quercetinase
Swissprots	Q6FHD2 O00625 Q5U0G0
Accessions	CAD33303 EAW98886 EAW98887 EAW98888 O00625 AK309656 BC002517 AAH02517 BT019583 AAV38390 BT019584 AAV38391 CR541822 CAG46621 DA686501 DQ891941 ABM82867 DQ895128 ABM86054 DT217415 Y07867 CAA69194 Y07868 CAA69195 NM_001018109 NP_001018119 NM_003662 NP_003653
Function	Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269\|PubMed:17288615, ECO:0000269\|PubMed:20010624, ECO:0000269\|PubMed:20711196, ECO:0000269\|PubMed:23716661}.
Subcellular Location	Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
Tissue Specificity	Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. {ECO:0000269\|PubMed:20089166, ECO:0000269\|PubMed:9079676}.

Pirin (1E8) Rat mAb - 9777 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rat
Clonality	Monoclonal
Clone	1E8

Western blot analysis of cell lysates from HeLa, NIH/3T3, C6 and COS cells, using Pirin (1E8) Rat mAb.

pirin (D-10) - sc-271623 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

pirin (D-10): sc-271623. Western blot analysis of pirin expression in HeLa whole cell lysate.

pirin (FL-290) - sc-134772 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

pirin (FL-290): sc-134772. Western blot analysis of pirin expression in HeLa (A), Hep G2 (B), THP-1 (C) and A549 (D) whole cell lysates.

pirin (D-12) - sc-271622 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

pirin (D-12): sc-271622. Western blot analysis of pirin expression in HeLa whole cell lysate.

pirin (C-20) - sc-48646 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

pirin (C-20): sc-48646. Western blot analysis of pirin expression in non-transfected 293T: sc-117752 (A), mouse pirin transfected 293T: sc-122594 (B) and HeLa (C) whole cell lysates.

Anti-Pirin antibody - ab169636 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-Pirin antibody (ab169636) at 1/500 dilution + Human spleen lysate at 50 µgdeveloped using the ECL technique

Anti-Pirin antibody - ab21202 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-Pirin antibody (ab21202) at 0.3 µg/ml + Human Heart lysate (35µg protein in RIPA buffer). developed using the ECL technique

Anti-Pirin antibody [2740C2] - ab51360 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2740C2

Anti-Pirin antibody [2740C2] (ab51360) at 1/200 dilution + HeLa whole cell lysate at 25 µgSecondaryAnti mouse IgG antibody at 1/2500 dilution

Anti-Pirin antibody [EPR11375(B)] - ab157212 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR11375(B)

All lanes : Anti-Pirin antibody [EPR11375(B)] (ab157212) at 1/1000 dilutionLane 1 : MCF-7 cell lysateLane 2 : HeLa cell lysateLane 3 : A431 cell lysateLane 4 : A375 cell lysateLysates/proteins at 10 µg per lane.

Anti-Pirin antibody [EPR11376] - ab172629 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR11376

All lanes : Anti-Pirin antibody [EPR11376] (ab172629) at 1/1000 dilutionLane 1 : MCF-7 cell lysateLane 2 : HeLa cell lysateLane 3 : HepG2 cell lysateLysates/proteins at 10 µg per lane.

Anti-Pirin / PIR Antibody (clone 2740C2) - LS-C342844 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2740C2

Western blot analysis of immunized recombinant protein, using anti-PIR monoclonal antibody.

Anti-Pirin / PIR Antibody - LS-C38246 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µl
Host	Rat
Clonality	Monoclonal

Anti-Pirin / PIR Antibody - LS-C74968 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

Anti-Pirin / PIR Antibody (C-Terminus) - LS-C131439 from LifeSpan Bioscience

Prices	$530.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-Pirin / PIR Antibody (aa213-262) - LS-C31790 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Pirin / PIR Antibody (C-Terminus) - LS-C31789 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

PIR / Pirin antibody LS-C31789 was used in IHC to stain formalin-fixed, paraffin-embedded human lung.

Anti-Pirin / PIR Antibody (N-Terminus) - LS-C55288 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Antibody (0.3 ug/ml) staining of Human Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Pirin / PIR Antibody (clone 2740C2) - LS-C184422 from LifeSpan Bioscience

Prices	$335.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	2740C2

Western blot of immunized recombinant protein using PIR antibody.

Pirin Antibody - NBP2-19840 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Pirin Antibody [NBP2-19840] - A. 50 ug mouse liver lysate/extract 12 % SDS-PAGE Pirin antibody dilution: 1:1000

Pirin Antibody - H00008544-B01 from Novus Biologicals

Host	Mouse
Clonality	Polyclonal

Western Blot: Pirin Antibody [H00008544-B01] - Western Blot analysis of PIR expression in human spleen.

Pirin Antibody - NBP1-87500 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Pirin Antibody - NB300-958 from Novus Biologicals

Prices	$299.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Western Blot: Pirin Antibody [NB300-958] - HEK293 overexpressing PIR and probed with (mock transfection in first lane).

Pirin Antibody (4D1) - H00008544-M03 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	4D1

Pirin Antibody - H00008544-D01P from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Pirin Antibody [H00008544-D01P] - PIR MaxPab rabbit polyclonal antibody. Western Blot analysis of PIR expression in human kidney.

Pirin Antibody - NBP1-33555 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Pirin Antibody [NBP1-33555] - Sample (30 ug of whole cell lysate) A: A431 B: Hela 12% SDS PAGE; antibody diluted at 1:1000.

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