| Gene Symbol |
PIR
|
| Entrez Gene |
8544
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pirin (iron-binding nuclear protein)
|
| Other Description |
pirin|probable quercetin 2,3-dioxygenase PIR|probable quercetinase
|
| Swissprots |
Q6FHD2 O00625 Q5U0G0
|
| Accessions |
CAD33303 EAW98886 EAW98887 EAW98888 O00625 AK309656 BC002517 AAH02517 BT019583 AAV38390 BT019584 AAV38391 CR541822 CAG46621 DA686501 DQ891941 ABM82867 DQ895128 ABM86054 DT217415 Y07867 CAA69194 Y07868 CAA69195 NM_001018109 NP_001018119 NM_003662 NP_003653
|
| Function |
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269|PubMed:17288615, ECO:0000269|PubMed:20010624, ECO:0000269|PubMed:20711196, ECO:0000269|PubMed:23716661}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
|
| Tissue Specificity |
Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}.
|