KNG1

Gene Symbol	KNG1
Entrez Gene	3827
Alt Symbol	BDK, BK, KNG
Species	Human
Gene Type	protein-coding
Description	kininogen 1
Other Description	HMWK|alpha-2-thiol proteinase inhibitor|bradykinin|fitzgerald factor|high molecular weight kininogen|kininogen-1|williams-Fitzgerald-Flaujeac factor
Swissprots	B2RCR2 Q6PAU9 A8K474 Q53EQ0 P01042 P01043 C9JEX1 Q7M4P1
Accessions	AAB59550 AAB59551 AAO61092 CBN73461 EAW78179 EAW78180 EAW78181 P01042 AI133186 AK223589 BAD97309 AK290839 BAF83528 AK298440 BAG60660 AK303768 BAG64734 AK315230 BAG37659 BC026253 AAH26253 BC060039 AAH60039 BG430928 CB148843 CD014130 DA537547 DC362362 K02566 AAA35497 NM_000893 NP_000884 NM_001102416 NP_001095886 NM_001166451 NP_001159923
Function	(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood
Subcellular Location	Secreted, extracellular space.
Tissue Specificity	Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. {ECO:0000269|PubMed:2076202}.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Kininogen-1 Lysate(Denatured) - H00003827-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

KNG1 overexpression lysate - LY432983 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

KNG1 293 Cell Lysate - 400356 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

HMW Kininogen Overexpression Lysate (Denatured) - H00003827-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

HMW Kininogen Overexpression Lysate (Native) - NBL1-12368 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

KNG1 Over-expression Lysate Product - GWB-D4EB51 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human KNG1 / BDK / Kininogen-1 HEK293 Cell Lysate (WB positive control) - 10529-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Kininogen (HMW) Deficient Plasma (EDTA) - D131104 from AssayPro Category Blood Product Prices $40.00 Sizes 1 ml Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Plasma (EDTA) - D131105 from AssayPro Category Blood Product Prices $200.00 Sizes 10 ml Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Plasma (EDTA) - D131106 from AssayPro Category Blood Product Prices $1,600.00 Sizes 100 ml (10 vials x 10 ml) Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Plasma (Heparin) - D131107 from AssayPro Category Blood Product Prices $40.00 Sizes 1 ml Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Plasma (Heparin) - D131108 from AssayPro Category Blood Product Prices $200.00 Sizes 10 ml Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Plasma (Heparin) - D131109 from AssayPro Category Blood Product Prices $1,600.00 Sizes 100 ml (10 vials x 10 ml) Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Plasma (Sodium Citrate) - D131101 from AssayPro Category Blood Product Prices $40.00 Sizes 1 ml Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Plasma (Sodium Citrate) - D131102 from AssayPro Category Blood Product Prices $200.00 Sizes 10 ml Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Plasma (Sodium Citrate) - D131103 from AssayPro Category Blood Product Prices $1,600.00 Sizes 100 ml (10 vials x 10 ml) Species Human Tissue Plasma

Human Kininogen (HMW) Deficient Serum - D131110 from AssayPro Category Blood Product Prices $40.00 Sizes 1 ml Species Human Tissue Serum

Human Kininogen (HMW) Deficient Serum - D131111 from AssayPro Category Blood Product Prices $200.00 Sizes 10 ml Species Human Tissue Serum

Human Kininogen (HMW) Deficient Serum - D131112 from AssayPro Category Blood Product Prices $1,600.00 Sizes 100 ml (10 vials x 10 ml) Species Human Tissue Serum

Kininogen/Kininostatin/Bradykinin Overexpression Lysate (Denatured) - H00003827-T03 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human KNG1 Human Cells Transfected Lysate (positive control) (denatured) - orb173478 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human KNG1 Knockdown Stable Cell Line - CSC-DC008334 from Creative biogene Category Cell Line Species Human

Search more