KNG1

Gene Symbol KNG1
Entrez Gene 3827
Alt Symbol BDK, BK, KNG
Species Human
Gene Type protein-coding
Description kininogen 1
Other Description HMWK|alpha-2-thiol proteinase inhibitor|bradykinin|fitzgerald factor|high molecular weight kininogen|kininogen-1|williams-Fitzgerald-Flaujeac factor
Swissprots B2RCR2 Q6PAU9 A8K474 Q53EQ0 P01042 P01043 C9JEX1 Q7M4P1
Accessions AAB59550 AAB59551 AAO61092 CBN73461 EAW78179 EAW78180 EAW78181 P01042 AI133186 AK223589 BAD97309 AK290839 BAF83528 AK298440 BAG60660 AK303768 BAG64734 AK315230 BAG37659 BC026253 AAH26253 BC060039 AAH60039 BG430928 CB148843 CD014130 DA537547 DC362362 K02566 AAA35497 NM_000893 NP_000884 NM_001102416 NP_001095886 NM_001166451 NP_001159923
Function (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood
Subcellular Location Secreted, extracellular space.
Tissue Specificity Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. {ECO:0000269|PubMed:2076202}.
Top Pathways Complement and coagulation cascades

bradykinin (K-15) - sc-14941 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Kininogen HC (2B5) - sc-23914 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Kininogen HC (2B5): sc-23914. Immunoperoxidase staining of formalin fixed, paraffin-embedded human platelets showing membrane localization.

Kininogen HC (H-5) - sc-166631 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Kininogen HC (H-5): sc-166631. Western blot analysis of Kininogen HC expression in Caki-1 whole cell lysate.

Kininogen HC (1.B.708) - sc-59580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Kininogen LC (C-16) - sc-25885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Kininogen LC (C11C1) - sc-23915 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Kininogen LC (C11C1): sc-23915. Immunofluorescence staining of methanol-fixed ECV304 cells showing cytoplasmic localization.

Kininogen LC (1.B.709) - sc-59581 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Kininogen LC (14J09) - sc-80524 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Bradykinin antibody - ab47686 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Bradykinin antibody - ab14391 from Abcam

Prices $370.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-HMW Kininogen antibody - ab79653 from Abcam

Prices $379.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab79653 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab79653, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-HMW Kininogen antibody (Biotin) - ab79654 from Abcam

Prices $372.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal

Anti-HMW Kininogen antibody [C11C1] - ab1004 from Abcam

Prices $387.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone C11C1
Image courtesy of an anonymous Abreview.See Abreview

Anti-HMW Kininogen Heavy Chain antibody [1.B.708] - ab14512 from Abcam

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1.B.708

Anti-HMW Kininogen Heavy Chain antibody [2B5] - ab1005 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B5

Anti-Kininogen 1 antibody - ab170475 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Kininogen 1 antibody (ab170475) at 1/100 dilution + Ramos cell lysate at 35 µg

Anti-Kininogen 1 antibody - ab97761 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Kininogen 1 antibody (ab97761) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-Kininogen 1 antibody - ab175386 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Kininogen 1 antibody (ab175386) at 1/500 dilution + Human plasma extract

Anti-Kininogen 1 antibody - ab191370 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embeddd Human small intestine tissue labeling Kininogen 1 with ab191370 at 7.5 µg/ml

Anti-Kininogen 1 antibody - ab193230 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Kininogen 1 antibody (ab193230) at 2 µg/mlLane 1 : EC109 whole cell lysateLane 2 : 293T whole cell lysateSecondarygoat polyclonal to rabbit IgG at 1/10000 dilution

Anti-Kininogen 1 antibody - ab185937 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Kininogen 1 antibody (ab185937) at 0.3 µg/ml + Human kidney lysate at 35 developed using the ECL technique

Anti-Kininogen 1 antibody (Biotin) - ab193015 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Kininogen 1 antibody [EPR6097] - ab124737 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6097
All lanes : Anti-Kininogen 1 antibody [EPR6097] (ab124737) at 1/10000 dilutionLane 1 : Human plasma lysateLane 2 : Human platelet lysateLane 3 : Human ovarian cancer lysatesLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Kininogen 1 antibody (FITC) - ab193054 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Kininogen 1 antibody [MM0437-11L36] - ab90457 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0437-11L36
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