Gene Symbol | Ephb1 |
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Entrez Gene | 270190 |
Alt Symbol | 9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net |
Species | Mouse |
Gene Type | protein-coding |
Description | Eph receptor B1 |
Other Description | ephrin type-B receptor 1 |
Swissprots | Q6PG23 Q8CBF3 B1B1C2 Q8CBE2 Q3UY27 |
Accessions | EDL21046 EDL21047 Q8CBF3 AK033966 AK036148 BAC29320 AK036211 BAC29348 AK039530 BAC30375 AK082061 BAC38401 AK135018 BAE22386 AK163703 BC057301 AAH57301 NM_001168296 NP_001161768 NM_173447 NP_775623 |
Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formatio |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome membrane {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:14691139}. |
Tissue Specificity | Expressed in neural stem and progenitor cells in the dentate gyrus. {ECO:0000269|PubMed:18057206}. |
Top Pathways | Axon guidance |
EphB1 CRISPR/Cas9 KO Plasmid (m) - sc-435419 from Santa Cruz Biotechnology
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EphB1 HDR Plasmid (m) - sc-435419-HDR from Santa Cruz Biotechnology
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EphB1 Double Nickase Plasmid (m) - sc-435419-NIC from Santa Cruz Biotechnology
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EphB1 Double Nickase Plasmid (m2) - sc-435419-NIC-2 from Santa Cruz Biotechnology
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EphB1 CRISPR Activation Plasmid (m) - sc-435419-ACT from Santa Cruz Biotechnology
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EphB1 CRISPR Activation Plasmid (m2) - sc-435419-ACT-2 from Santa Cruz Biotechnology
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EphB1 Lentiviral Activation Particles (m) - sc-435419-LAC from Santa Cruz Biotechnology
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EphB1 Lentiviral Activation Particles (m2) - sc-435419-LAC-2 from Santa Cruz Biotechnology
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EphB1 siRNA (m) - sc-39948 from Santa Cruz Biotechnology
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EphB1 shRNA Plasmid (m) - sc-39948-SH from Santa Cruz Biotechnology
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EphB1 shRNA (m) Lentiviral Particles - sc-39948-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN30701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30701 from Sigma-Aldrich
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EPHB1 siRNA (Mouse) - CRN4132 from Cohesion Biosciences
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EPHB1 - MBS8220138 from MyBioSource
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Mouse EPHB1 siRNA - orb293607 from Biorbyt
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EPHB1 shRNA Plasmid (Mouse) - CHN4132 from Cohesion Biosciences
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