Gene Symbol | Ephb1 |
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Entrez Gene | 270190 |
Alt Symbol | 9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net |
Species | Mouse |
Gene Type | protein-coding |
Description | Eph receptor B1 |
Other Description | ephrin type-B receptor 1 |
Swissprots | Q6PG23 Q8CBF3 B1B1C2 Q8CBE2 Q3UY27 |
Accessions | EDL21046 EDL21047 Q8CBF3 AK033966 AK036148 BAC29320 AK036211 BAC29348 AK039530 BAC30375 AK082061 BAC38401 AK135018 BAE22386 AK163703 BC057301 AAH57301 NM_001168296 NP_001161768 NM_173447 NP_775623 |
Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formatio |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome membrane {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:14691139}. |
Tissue Specificity | Expressed in neural stem and progenitor cells in the dentate gyrus. {ECO:0000269|PubMed:18057206}. |
Top Pathways | Axon guidance |
Mouse Cek 6 protein - orb84444 from Biorbyt
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Recombinant Mouse Eph Receptor B1, GST-tagged, Active - Ephb1-303M from Creative Biomart
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EPHB1 / EPHT2 - PN201535 from Elabscience
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Mouse EphB1 / EPHT2 Protein (His Tag) - 50479-M08H-100 from Sino Biological
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Recombinant Mouse Ephrin type-B receptor 1(Ephb1) - CSB-YP806509MO CSB-EP806509MO CSB-BP806509MO CSB-MP806509MO from Cusabio
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Mouse EphB1 / EPHT2 Protein (His & GST Tag) - 50479-M20B-20 from Sino Biological
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Recombinant Mouse EphB1 / EPHT2 Protein (His & GST tag) - PKSM040302 from Elabscience
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Recombinant Mouse EphB1 / EPHT2 Protein (His tag) - PKSM040659 from Elabscience
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Mouse-Ephb1-Blocking-Peptide-Center - BP20937a from Abgent, a WuXi AppTec company
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Mouse-Ephb1-Blocking-Peptide-Center - BP20899a from Abgent, a WuXi AppTec company
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Mouse-Ephb1-Blocking-Peptide-Center - BP20994a from Abgent, a WuXi AppTec company
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Mouse EphB1 / EPHT2 Protein (His Tag) - 50479-M08H from ABclonal
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Mouse EphB1 / EPHT2 Protein (His & GST Tag) - 50479-M20B from ABclonal
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EphB1 / EPHT2, Recombinant Protein - MBS2546960 from MyBioSource
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EphB1 / EPHT2, Recombinant Protein - MBS2546608 from MyBioSource
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Ephrin type-B receptor 1 (Ephb1), Recombinant Protein - MBS1407722 from MyBioSource
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