TLR8

Gene Symbol TLR8
Entrez Gene 51311
Alt Symbol CD288
Species Human
Gene Type protein-coding
Description toll-like receptor 8
Other Description -
Swissprots D1CS76 B3Y654 D1CS70 Q9NR97 Q6UXL6 Q9NYG9 Q495P4
Accessions AAZ95433 AAZ95434 AAZ95435 AAZ95436 AAZ95437 AAZ95438 AAZ95439 AAZ95440 AAZ95441 EAW98808 EAW98809 Q9NR97 AB445666 BAG55063 AF245703 AAF78036 AF246971 AAF64061 AK075117 BAC11412 AK297024 BAG59554 AK307562 AK314240 AY358296 AAQ88663 BC101074 AAI01075 BC101075 AAI01076 BC101076 AAI01077 BC101077 AAI01078 XM_011545529 XP_011543831 XM_011545530 XP_011543832 NM_016610 NP_057694 NM_138636 NP_619542
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23520111}.
Subcellular Location Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
Top Pathways Toll-like receptor signaling pathway

Toll-like Receptor 8 (D3Z6J) Rabbit mAb - 11886 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3Z6J
Western blot analysis of extracts from THP-1 cells differentiated with TPA #4174 (80 nM, 16 hr), untreated (-) or treated with Human Interferon-γ (hIFN-γ) #8901 (20 ng/mL, 8 hr; +), using Toll-like Receptor 8 (D3Z6J) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

TLR8 (D-14) - sc-17585 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR8 (D-8) - sc-373760 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TLR8 (D-8): sc-373760. Western blot analysis of human recombinant TLR8.

TLR8 (H-114) - sc-25467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TLR8 (H-114): sc-25467. Western blot analysis of TLR8 expression in SW480 whole cell lysate.

TLR8 (S-15) - sc-32995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR8 (S-16) - sc-13213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR8 (9A6) - sc-135584 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TLR8 (9A6): sc-135584. Western blot analysis of TLR8 expression in human TLR8 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-TLR8 antibody - ab24185 from Abcam

Prices $382.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TLR8 antibody (ab24185) at 0.5 µg/mlLane 2 : Anti-TLR8 antibody (ab24185) at 1 µg/mlLane 3 : Anti-TLR8 antibody (ab24185) at 2 µg/mlLane 1 : Daudi Cell lysateLane 2 : Daudi Cell lysateLane 3 : Daudi Cell lysate

Anti-TLR8 antibody - ab180610 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of MCF7 cells using ab180610. Blue DAPI for nuclear staining.

Anti-TLR8 antibody - ab53630 from Abcam

Prices $379.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab53630 at 1/250 dilution staining TLR8 in mouse spleen by Immunohistochemistry, Paraffin embedded tissue.

Anti-TLR8 antibody [44C143] - ab85859 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 44C143
ab85859 at 5 µg/ml staining TLR8 in formalin fixed and paraffin embedded brain cortex

Anti-TLR8 antibody [44C143] - ab12120 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 44C143

Anti-TLR8 antibody [44C143] (Phycoerythrin) - ab45097 from Abcam

Prices $382.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 44C143
ab45097 at 2µg/106 cells staining Ramos cells by flow cytometry analysis. The shaded histogram represents cells without antibody, green represents isotype control and red represents ab45097.

Anti-TLR8 antibody - C-terminal - ab172931 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue labeling TLR8 with ab172931 at 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

Anti-TLR8 antibody - C-terminal - ab191578 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human thymus tissue labeling TLR8 with ab191578 at 5 µg/ml.

Anti-TLR8 Antibody (C-Terminus, FITC) - LS-C220895 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLR8 Antibody (C-Terminus, Azide-free, HRP) - LS-C220896 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLR8 Antibody (C-Terminus, PE) - LS-C220897 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLR8 Antibody (aa965-995, AP) - LS-C220898 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLR8 Antibody (aa965-995, APC) - LS-C220899 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLR8 Antibody (aa434-463) - LS-C161923 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TLR8 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lung tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TLR8 Antibody (aa965-995, Biotin) - LS-C220900 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLR8 Antibody (aa750-850, clone 44C143, PE) - LS-C148147 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 44C143
Intracellular flow analysis of TLR8 in Ramos cells using 2 ug of LS-C148147. Shaded histogram represents Ramos cells without antibody; green represents isotype control, ; red represents anti-TLR8 antibody.

Anti-TLR8 Antibody (aa965-995, FITC) - LS-C220901 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TLR8 Antibody (aa965-995, Azide-free, HRP) - LS-C220902 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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