| Gene Symbol |
TLR8
|
| Entrez Gene |
51311
|
| Alt Symbol |
CD288
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
toll-like receptor 8
|
| Other Description |
-
|
| Swissprots |
D1CS76 B3Y654 D1CS70 Q9NR97 Q6UXL6 Q9NYG9 Q495P4
|
| Accessions |
AAZ95433 AAZ95434 AAZ95435 AAZ95436 AAZ95437 AAZ95438 AAZ95439 AAZ95440 AAZ95441 EAW98808 EAW98809 Q9NR97 AB445666 BAG55063 AF245703 AAF78036 AF246971 AAF64061 AK075117 BAC11412 AK297024 BAG59554 AK307562 AK314240 AY358296 AAQ88663 BC101074 AAI01075 BC101075 AAI01076 BC101076 AAI01077 BC101077 AAI01078 XM_011545529 XP_011543831 XM_011545530 XP_011543832 NM_016610 NP_057694 NM_138636 NP_619542
|
| Function |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23520111}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
|
| Top Pathways |
Toll-like receptor signaling pathway
|
![Western Blot: Human TLR8 Stable Cell Line [NBP2-26271] - analysis of TLR8 expression in the TLR8 stable cell line using an HA antibody (20 ug total protein/lane). Legend. Vect: Vector control stable cell line; TLR8: TLR8 stable cell line.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10746_Human%2520TLR8%2520Stable%2520Cell%2520Line-Western%2520Blot-NBP2-26271-img0006.jpg)
![Flow Cytometry: Human TLR8 NF-kB/SEAP - (SEAPorter™) Stable Reporter Cell Line [NBP2-26279] - Intracellular staining of TLR8 in the TLR8 reporter cell line was analyzed by flow cytometry using a PE conjugated TLR8 antibody. Flow samples were prepared using the Intracellular TLR Staining Flow Kit. Purple: Cells without antibody; Green: NF-kB/SEAPorterTM HEK 293 cell line stained with 2 ug anti-TLR8-PE. Red: TLR8 reporter line stained with anti-TLR8-PE.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10731_Human-TLR8-NF-kB-SEAP---(SEAPorter(TM))-Stable-Reporter-Cell-Line-Flow-Cytometry-NBP2-26279-img0013.jpg)