| Gene Symbol | COPZ2 |
|---|---|
| Entrez Gene | 51226 |
| Alt Symbol | zeta2-COP |
| Species | Human |
| Gene Type | protein-coding |
| Description | coatomer protein complex, subunit zeta 2 |
| Other Description | coatomer subunit zeta-2|nonclathrin coat protein zeta-COP|zeta-2 COP|zeta-2-coat protein |
| Swissprots | Q9P299 |
| Accessions | EAW94769 Q9P299 AB037938 BAA90670 AB047849 BAB17660 BC015924 AAH15924 BQ002984 BQ576336 DQ893053 ABM83979 DQ896301 ABM87300 HY179834 XM_011524874 XP_011523176 XR_934471 XR_934472 XR_934473 XR_934474 NM_016429 NP_057513 |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network. {ECO:0000250}. |
COPZ2 CRISPR/Cas9 KO Plasmid (h) - sc-412150 from Santa Cruz Biotechnology
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COPZ2 HDR Plasmid (h) - sc-412150-HDR from Santa Cruz Biotechnology
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COPZ2 Double Nickase Plasmid (h) - sc-412150-NIC from Santa Cruz Biotechnology
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COPZ2 Double Nickase Plasmid (h2) - sc-412150-NIC-2 from Santa Cruz Biotechnology
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COPZ2 CRISPR Activation Plasmid (h) - sc-412150-ACT from Santa Cruz Biotechnology
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COPZ2 CRISPR Activation Plasmid (h2) - sc-412150-ACT-2 from Santa Cruz Biotechnology
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COPZ2 Lentiviral Activation Particles (h) - sc-412150-LAC from Santa Cruz Biotechnology
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COPZ2 Lentiviral Activation Particles (h2) - sc-412150-LAC-2 from Santa Cruz Biotechnology
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COPZ2 siRNA (h) - sc-41206 from Santa Cruz Biotechnology
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COPZ2 shRNA Plasmid (h) - sc-41206-SH from Santa Cruz Biotechnology
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COPZ2 shRNA (h) Lentiviral Particles - sc-41206-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU051951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6441 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01615 from Sigma-Aldrich
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COPZ2 siRNA (Human) - CRH9617 from Cohesion Biosciences
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COPZ2 - MBS8233857 from MyBioSource
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shRNA set against Human COP (NM_016429.2) - SHH267713 from Creative biogene
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shRNA set against Human COPZ2(NM_016429.2) - SHG193015 from Creative biogene
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Human COPZ2 siRNA - orb270119 from Biorbyt
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COPZ2 shRNA Plasmid (Human) - CHH9617 from Cohesion Biosciences
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COPZ2 miRNA 3'UTR clone - MiUTR1H-02364 from Creative biogene
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