Gene Symbol | COPZ2 |
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Entrez Gene | 51226 |
Alt Symbol | zeta2-COP |
Species | Human |
Gene Type | protein-coding |
Description | coatomer protein complex, subunit zeta 2 |
Other Description | coatomer subunit zeta-2|nonclathrin coat protein zeta-COP|zeta-2 COP|zeta-2-coat protein |
Swissprots | Q9P299 |
Accessions | EAW94769 Q9P299 AB037938 BAA90670 AB047849 BAB17660 BC015924 AAH15924 BQ002984 BQ576336 DQ893053 ABM83979 DQ896301 ABM87300 HY179834 XM_011524874 XP_011523176 XR_934471 XR_934472 XR_934473 XR_934474 NM_016429 NP_057513 |
Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network. {ECO:0000250}. |
Human COPZ2 full length protein - ab162463 from Abcam
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COPZ2 Antibody Blocking Peptide - LS-E7766 from LifeSpan Bioscience
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Coatomer protein complex, subunit zeta 2 Recombinant Protein - H00051226-P01 from Novus Biologicals
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COPZ2-Antibody-C-term-Blocking-Peptide - BP5175b from Abgent, a WuXi AppTec company
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Coatomer subunit zeta-2 (COPZ2) - H00051226-P01-10 from Acris Antibodies
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Coatomer subunit zeta-2 (COPZ2) - H00051226-P01-25 from Acris Antibodies
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COPZ2 fusion protein - Ag14184 from Proteintech Group
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Recombinant Human COPZ2, GST-tagged - COPZ2-11466H from Creative Biomart
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Recombinant Human Coatomer subunit zeta-2(COPZ2) - CSB-YP882176HU CSB-EP882176HU CSB-BP882176HU CSB-MP882176HU from Cusabio
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Coatomer subunit zeta-2 (COPZ2) - TP304853 from Acris Antibodies
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Coatomer protein complex, subunit zeta 2 Recombinant Protein Antigen - NBP2-30435PEP from Novus Biologicals
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COPZ2 Peptide, Human - M34GP03508H from Creative Peptides
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Coatomer subunit zeta-2 (COPZ2), Recombinant Protein - MBS1306776 from MyBioSource
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