SP140

Gene Symbol SP140
Entrez Gene 11262
Alt Symbol LYSP100, LYSP100-A, LYSP100-B
Species Human
Gene Type protein-coding
Description SP140 nuclear body protein
Other Description lymphoid-restricted homolog of Sp100|lymphoid-specific SP100 homolog|nuclear autoantigen Sp-140|nuclear body protein SP140|speckled 140 kDa
Swissprots E9PFJ6 E7EUR5 Q3KR17 Q4ZG66 Q92881 E7ESH9 Q0VGE5 Q6NSG4 Q96TG3 Q13342 Q53TG1 Q13341
Accessions AAX88868 AAX93282 EAW70920 EAW70921 EAW70922 Q13342 AA741304 AK301267 BAG62830 AK301317 BAG62868 BC038091 AAH38091 BC054890 AAH54890 BC070160 AAH70160 BC105743 AAI05744 BC105744 AAI05745 BC105960 AAI05961 DC391925 U36499 AAB18616 U36500 AAB18617 U63420 AAC50817 XM_005246252 XP_005246309 XM_005246253 XP_005246310 XM_005246254 XP_005246311 XM_005246255 XP_005246312 XM_005246256 XP_005246313 XM_006712223 XP_006712286 XM_011510515 XP_011508817 XM_011510516 XP_011508818 XM_011510517 XP_011508819 XM_011510518 XP_011508820 XM_011510519 XP_011508821 XM_011510520 XP_011508822 XM_011510521 XP_011508823 XM_011510522 XP_011508824 XM_011510523 XP_011508825 XR_922832 NM_001005176 NP_001005176 NM_001278451 NP_001265380 NM_001278452 NP_001265381 NM_001278453 NP_001265382 NM_007237 NP_009168
Function Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}.
Subcellular Location Nucleus {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Nucleus, PML body {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Cytoplasm {ECO:0000269|PubMed:8695863}. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863). Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577). {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}.
Tissue Specificity High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon (PubMed:8695863, PubMed:8910577.) Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:8910577). Not detected in brain, liver and muscle (PubMed:8695863). {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}.

SP140 (E-14) - sc-109035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SP140 (E-14): sc-109035. Western blot analysis of SP140 expression in Daudi whole cell lysate.

SP140 (N-12) - sc-109036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SP140 antibody - ab171141 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling SP140 with ab171141 at 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

Anti-SP140 antibody - ab24341 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SP140 antibody (ab24341) at 5 µg/ml + Raji cell lysate.SecondaryHRP conjugated rabbit anti SP140 IgG, at a dilution of 1/50000 - 1/100000.

Anti-SP140 antibody - ab172695 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SP140 antibody (ab172695) at 1 µg/mlLane 1 : SP140-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-SP140 antibody [3F9] - ab124337 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3F9
ab124337, at 5 µg/ml, staining SP140 in formalin-fixed, paraffin-embedded Human testis tissue by Immunohistochemistry.

Anti-SP140 Antibody (aa272-301, AP) - LS-C270055 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP140 Antibody (aa272-301, APC) - LS-C270056 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP140 Antibody (aa272-301, Biotin) - LS-C270057 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP140 Antibody (aa272-301, FITC) - LS-C270058 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP140 Antibody (aa272-301, Azide-free, HRP) - LS-C270059 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP140 Antibody (aa272-301, PE) - LS-C270060 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP140 Antibody (aa279-309) - LS-C325295 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SP140 Antibody (aa39-88) - LS-C30581 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SP140 antibody LS-C30581 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-SP140 Antibody (aa443-655) - LS-C315039 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SP140.

Anti-SP140 Antibody (clone 3F9) IHC-plus™ - LS-B6030 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3F9
Anti-SP140 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6030 concentration 5 ug/ml.

Anti-SP140 Antibody (aa272-301) - LS-C161409 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SP140 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

SP140 Antibody - NBP1-80009 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SP140 Antibody [NBP1-80009] - Human Lung Tumor, Antibody Dilution: 0.5 ug/ml.

SP140 Antibody - NBP1-81275 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SP140 Antibody [NBP1-81275] - Staining of human lymph node shows moderate nuclear positivity in reaction center cells and strong nuclear positivity in lymphoid cells outside reaction centre.

SP140 Antibody (3F9) - H00011262-BO1 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 3F9
Immunohistochemistry-Paraffin: SP140 Antibody (3F9) [H00011262-BO1] - Human kidney. Antibody concentration 1.5 ug/ml

SP140 Antibody (3F9) - H00011262-M07 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F9
Immunocytochemistry/Immunofluorescence: SP140 Antibody (3F9) [H00011262-M07] - Analysis of monoclonal antibody to SP140 on HeLa cell. Antibody concentration 10 ug/ml

SP140 Antibody - H00011262-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SP140 Antibody [H00011262-B01P] - Analysis of SP140 expression in transfected 293T cell line by SP140 polyclonal antibody. Lane 1: SP140 transfected lysate(18.92 KDa). Lane 2: Non-transfected lysate.

Anti-SP140 antibody produced in mouse - SAB1408825 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SP140: <B>Cat. No. SAB1408825</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~18.9 kDa using SP140 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Monoclonal Anti-SP140 antibody produced in mouse - SAB1402539 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F9
<B>Immunohistochemistry</B><BR/>Monoclonal Anti-SP140, antibody produced in mouse, clone 3F9, purified immunoglobulin: <B>Cat. No. SAB1402539</B>: Antibody concentration: 1.5 μg/mL using human kidney tissue.

Anti-SP140 antibody produced in rabbit - HPA006162 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SP140: <B>Cat. No. HPA006162</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymph node shows moderate nuclear positivity in reaction center cells and strong nuclear positivity in lymphoid cells outside reaction centre.
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