| Gene Symbol |
SP140
|
| Entrez Gene |
11262
|
| Alt Symbol |
LYSP100, LYSP100-A, LYSP100-B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SP140 nuclear body protein
|
| Other Description |
lymphoid-restricted homolog of Sp100|lymphoid-specific SP100 homolog|nuclear autoantigen Sp-140|nuclear body protein SP140|speckled 140 kDa
|
| Swissprots |
E9PFJ6 E7EUR5 Q3KR17 Q4ZG66 Q92881 E7ESH9 Q0VGE5 Q6NSG4 Q96TG3 Q13342 Q53TG1 Q13341
|
| Accessions |
AAX88868 AAX93282 EAW70920 EAW70921 EAW70922 Q13342 AA741304 AK301267 BAG62830 AK301317 BAG62868 BC038091 AAH38091 BC054890 AAH54890 BC070160 AAH70160 BC105743 AAI05744 BC105744 AAI05745 BC105960 AAI05961 DC391925 U36499 AAB18616 U36500 AAB18617 U63420 AAC50817 XM_005246252 XP_005246309 XM_005246253 XP_005246310 XM_005246254 XP_005246311 XM_005246255 XP_005246312 XM_005246256 XP_005246313 XM_006712223 XP_006712286 XM_011510515 XP_011508817 XM_011510516 XP_011508818 XM_011510517 XP_011508819 XM_011510518 XP_011508820 XM_011510519 XP_011508821 XM_011510520 XP_011508822 XM_011510521 XP_011508823 XM_011510522 XP_011508824 XM_011510523 XP_011508825 XR_922832 NM_001005176 NP_001005176 NM_001278451 NP_001265380 NM_001278452 NP_001265381 NM_001278453 NP_001265382 NM_007237 NP_009168
|
| Function |
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Nucleus, PML body {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Cytoplasm {ECO:0000269|PubMed:8695863}. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863). Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577). {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}.
|
| Tissue Specificity |
High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon (PubMed:8695863, PubMed:8910577.) Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:8910577). Not detected in brain, liver and muscle (PubMed:8695863). {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}.
|