Gene Symbol | Thap11 |
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Entrez Gene | 59016 |
Alt Symbol | 2810036E22Rik, AB041579, CTG-B43a, CTG-B45d, Ronin |
Species | Mouse |
Gene Type | protein-coding |
Description | THAP domain containing 11 |
Other Description | THAP domain-containing protein 11 |
Swissprots | Q99KZ0 Q3TCZ5 Q9JJD0 |
Accessions | EDL11318 Q9JJD0 AB041579 BAA95063 AK165981 BAE38498 AK166109 AK170457 BAE41810 AK210001 BC003949 AAH03949 BC138966 AAI38967 BC138987 AAI38988 NM_021513 NP_067488 |
Function | Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers. {ECO:0000269|PubMed:18585351}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18585351}. Cytoplasm {ECO:0000269|PubMed:18585351}. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. |
Tissue Specificity | Mainly restricted to pluripotent cells of the developing embryo, to oocytes, and to certain regions of the adult brain. {ECO:0000269|PubMed:18585351}. |
THAP11 CRISPR/Cas9 KO Plasmid (m) - sc-425562 from Santa Cruz Biotechnology
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THAP11 HDR Plasmid (m) - sc-425562-HDR from Santa Cruz Biotechnology
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THAP11 Double Nickase Plasmid (m) - sc-425562-NIC from Santa Cruz Biotechnology
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THAP11 Double Nickase Plasmid (m2) - sc-425562-NIC-2 from Santa Cruz Biotechnology
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THAP11 CRISPR Activation Plasmid (m) - sc-425562-ACT from Santa Cruz Biotechnology
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THAP11 CRISPR Activation Plasmid (m2) - sc-425562-ACT-2 from Santa Cruz Biotechnology
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THAP11 Lentiviral Activation Particles (m) - sc-425562-LAC from Santa Cruz Biotechnology
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THAP11 Lentiviral Activation Particles (m2) - sc-425562-LAC-2 from Santa Cruz Biotechnology
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THAP11 siRNA (m) - sc-154245 from Santa Cruz Biotechnology
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THAP11 shRNA Plasmid (m) - sc-154245-SH from Santa Cruz Biotechnology
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THAP11 shRNA (m) Lentiviral Particles - sc-154245-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU037761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42789 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42789 from Sigma-Aldrich
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THAP11 siRNA (Mouse) - CRM6172 from Cohesion Biosciences
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THAP11 - MBS8212426 from MyBioSource
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shRNA set against Mouse THAP11 (NM_021513.2) - SHH426696 from Creative biogene
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Mouse THAP11 siRNA - orb285648 from Biorbyt
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THAP11 shRNA Plasmid (Mouse) - CHM6172 from Cohesion Biosciences
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