| Gene Symbol |
Thap11
|
| Entrez Gene |
59016
|
| Alt Symbol |
2810036E22Rik, AB041579, CTG-B43a, CTG-B45d, Ronin
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
THAP domain containing 11
|
| Other Description |
THAP domain-containing protein 11
|
| Swissprots |
Q99KZ0 Q3TCZ5 Q9JJD0
|
| Accessions |
EDL11318 Q9JJD0 AB041579 BAA95063 AK165981 BAE38498 AK166109 AK170457 BAE41810 AK210001 BC003949 AAH03949 BC138966 AAI38967 BC138987 AAI38988 NM_021513 NP_067488
|
| Function |
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers. {ECO:0000269|PubMed:18585351}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18585351}. Cytoplasm {ECO:0000269|PubMed:18585351}. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus.
|
| Tissue Specificity |
Mainly restricted to pluripotent cells of the developing embryo, to oocytes, and to certain regions of the adult brain. {ECO:0000269|PubMed:18585351}.
|