Gene Symbol | PPAP2B |
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Entrez Gene | 8613 |
Alt Symbol | Dri42, LPP3, PAP2B, VCIP |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidic acid phosphatase type 2B |
Other Description | PAP2 beta|lipid phosphate phosphohydrolase 3|phosphatidate phosphohydrolase type 2b|type-2 phosphatidic acid phosphatase-beta|vascular endothelial growth factor and type I collagen inducible |
Swissprots | Q99782 Q96GW0 O14495 Q5U0F7 D3DQ52 B2R651 |
Accessions | EAX06651 EAX06652 EAX06653 O14495 AB000889 BAA22594 AF017786 AAC63433 AF043329 AAD02271 AF480883 AAO84481 AK123105 AK312439 BAG35348 BC009196 AAH09196 BM471786 BM719257 BQ027458 BT019589 AAV38396 BU608248 BU616092 DA580891 DQ893521 ABM84447 DQ895944 ABM86870 U79294 AAB50222 NM_003713 NP_003704 NM_177414 |
Function | Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions. |
Subcellular Location | Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Ubiquitously expressed. Highly expressed in heart and placenta. |
Top Pathways | Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism |
PAP-2b (C-17) - sc-51396 from Santa Cruz Biotechnology
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PAP-2b (N-14) - sc-51398 from Santa Cruz Biotechnology
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Anti-Phosphatidic acid phosphatase type 2B antibody [ZV002] - ab52581 from Abcam
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Anti-LPP3 / PPAP2B Antibody - LS-C26806 from LifeSpan Bioscience
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Anti-LPP3 / PPAP2B Antibody IHC-plus⢠- LS-B623 from LifeSpan Bioscience
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PPAP2B Antibody - NBP1-82825 from Novus Biologicals
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PPAP2B Antibody - NBP1-02866 from Novus Biologicals
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PPAP2B Antibody - H00008613-A01 from Novus Biologicals
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PAP2B Polyclonal Antibody - bs-4127R from Bioss
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Anti-PPAP2B antibody produced in rabbit - HPA028892 from Sigma-Aldrich
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Anti-PPAP2B (21-35) antibody produced in rabbit - SAB1100866 from Sigma-Aldrich
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PPAP2B-Antibody-N-term - AP21245a from Abgent, a WuXi AppTec company
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PAP2B antibody - orb6643 from Biorbyt
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PPAP2B Antibody (OABF01401) - OABF01401 from Aviva Systems Biology
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Anti -LPP3 (Lipid Phosphate Phosphohydrolase 3, PAP2-beta, Phosphatidate Phosphohydrolasetype 2b, Phosphatidic Acid Phosphatase 2b, PAP-2b, PAP2b, Vascular Endothelial GrowthFactor and Type I Collagen-inducible Protein, VCIP, PPAP2B) - 215356 from USBiological Life Science
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PAP2B antibody (FITC) - orb9491 from Biorbyt
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LPP3 antibody - orb108866 from Biorbyt
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PAP2B Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-4127R-A350 from Bioss
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PAP2B Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-4127R-A488 from Bioss
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PAP2B Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-4127R-A555 from Bioss
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PAP2B Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-4127R-A647 from Bioss
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PAP2B Polyclonal Antibody, Cy3 Conjugated - bs-4127R-Cy3 from Bioss
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PAP2B Polyclonal Antibody, Cy5 Conjugated - bs-4127R-Cy5 from Bioss
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PAP2B Polyclonal Antibody, Cy5.5 Conjugated - bs-4127R-Cy5.5 from Bioss
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PAP2B Polyclonal Antibody, Cy7 Conjugated - bs-4127R-Cy7 from Bioss
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