Gene Symbol | PSMB11 |
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Entrez Gene | 122706 |
Alt Symbol | BETA5T |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) subunit, beta type, 11 |
Other Description | proteasome subunit beta 5T|proteasome subunit beta type-11|proteasome subunit beta-5t |
Swissprots | A5LHX3 |
Accessions | A5LHX3 AB299437 BAF63540 AK122797 BAG53735 NM_001099780 NP_001093250 |
Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}. |
Top Pathways | Proteasome |
PSMB11 CRISPR/Cas9 KO Plasmid (h) - sc-408547 from Santa Cruz Biotechnology
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PSMB11 HDR Plasmid (h) - sc-408547-HDR from Santa Cruz Biotechnology
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PSMB11 Double Nickase Plasmid (h) - sc-408547-NIC from Santa Cruz Biotechnology
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PSMB11 Double Nickase Plasmid (h2) - sc-408547-NIC-2 from Santa Cruz Biotechnology
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PSMB11 CRISPR Activation Plasmid (h) - sc-408547-ACT from Santa Cruz Biotechnology
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PSMB11 CRISPR Activation Plasmid (h2) - sc-408547-ACT-2 from Santa Cruz Biotechnology
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PSMB11 Lentiviral Activation Particles (h) - sc-408547-LAC from Santa Cruz Biotechnology
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PSMB11 Lentiviral Activation Particles (h2) - sc-408547-LAC-2 from Santa Cruz Biotechnology
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PSMB11 siRNA (h) - sc-92455 from Santa Cruz Biotechnology
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PSMB11 shRNA Plasmid (h) - sc-92455-SH from Santa Cruz Biotechnology
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PSMB11 shRNA (h) Lentiviral Particles - sc-92455-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN17598 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17598 from Sigma-Aldrich
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PSMB11 siRNA (Human) - CRJ4706 from Cohesion Biosciences
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shRNA set against Human Psmb11 (NM_001099780.1) - SHH385156 from Creative biogene
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Human PSMB11 siRNA - orb275207 from Biorbyt
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PSMB11 shRNA Plasmid (Human) - CHJ4706 from Cohesion Biosciences
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PSMB11 miRNA 3'UTR clone - MiUTR4H-TG07151 from Creative biogene
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