Gene Symbol | ATF7IP2 |
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Entrez Gene | 80063 |
Alt Symbol | MCAF2 |
Species | Human |
Gene Type | protein-coding |
Description | activating transcription factor 7 interacting protein 2 |
Other Description | ATF7-interacting protein 2|MBD1-containing chromatin associated factor 2|MBD1-containing chromatin-associated factor 2|activating transcription factor 7-interacting protein 2 |
Swissprots | Q8N9X8 Q6IS97 Q5U623 Q658U2 Q53EZ7 B2RNR2 Q9H9L6 |
Accessions | EAW85183 EAW85184 Q5U623 AK022730 BAB14209 AK093414 BAC04157 AK223492 BAD97212 AK296565 BAG59185 AK299040 BAG61114 AL832987 CAH56323 AY560615 AAT66299 BC033891 AAH33891 BC069695 AAH69695 BC069713 AAH69713 BC069730 AAH69730 BC137079 AAI37080 BC144468 BI459223 XM_006720953 XP_006721016 XM_006720954 XP_006721017 XM_011522666 XP_011520968 NM_001256160 NP_001243089 NM_024997 NP_079273 NR_045815 NR_045816 |
Function | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). {ECO:0000305}. |
Subcellular Location | Nucleus. |
MCAF2 CRISPR/Cas9 KO Plasmid (h) - sc-413331 from Santa Cruz Biotechnology
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MCAF2 HDR Plasmid (h) - sc-413331-HDR from Santa Cruz Biotechnology
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MCAF2 Double Nickase Plasmid (h) - sc-413331-NIC from Santa Cruz Biotechnology
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MCAF2 Double Nickase Plasmid (h2) - sc-413331-NIC-2 from Santa Cruz Biotechnology
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MCAF2 CRISPR Activation Plasmid (h) - sc-413331-ACT from Santa Cruz Biotechnology
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MCAF2 CRISPR Activation Plasmid (h2) - sc-413331-ACT-2 from Santa Cruz Biotechnology
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MCAF2 Lentiviral Activation Particles (h) - sc-413331-LAC from Santa Cruz Biotechnology
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MCAF2 Lentiviral Activation Particles (h2) - sc-413331-LAC-2 from Santa Cruz Biotechnology
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MCAF2 siRNA (h) - sc-93392 from Santa Cruz Biotechnology
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MCAF2 shRNA Plasmid (h) - sc-93392-SH from Santa Cruz Biotechnology
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MCAF2 shRNA (h) Lentiviral Particles - sc-93392-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU060571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3641 from Sigma-Aldrich
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ATF7IP2 siRNA (Human) - CRJ2743 from Cohesion Biosciences
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ATF7IP2 - MBS8239602 from MyBioSource
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shRNA set against Human ATF7IP2 (NM_024997.3) - SHH242002 from Creative biogene
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Human ATF7IP2 siRNA - orb273244 from Biorbyt
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ATF7IP2 shRNA Plasmid (Human) - CHJ2743 from Cohesion Biosciences
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ATF7IP2 miRNA 3'UTR clone - MiUTR3H-12994 from Creative biogene
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