POLR1A

Gene Symbol POLR1A
Entrez Gene 25885
Alt Symbol A190, RPA1, RPA194, RPO1-4, RPO14
Species Human
Gene Type protein-coding
Description polymerase (RNA) I polypeptide A, 194kDa
Other Description DNA-directed RNA polymerase I largest subunit|DNA-directed RNA polymerase I subunit A|DNA-directed RNA polymerase I subunit A1|DNA-directed RNA polymerase I subunit RPA1|RNA polymerase I 194 kDa subunit|RNA polymerase I subunit A1
Swissprots Q0VG05 Q9UFT9 B7Z7T0 O95602 D6W5M0 Q9UEH0
Accessions AAY24277 EAW99467 EAW99468 EAW99469 O95602 AK025568 BAB15171 AK294447 BAH11770 AK302458 BAH13716 AK304131 BAH14113 AK307490 AL117467 CAB55942 BC017115 AAH17115 BC073968 BC117173 AAI17174 BC126303 AAI26304 BC143345 AAI43346 BP363163 U33460 AAC99959 XM_006711983 XP_006712046 NM_015425 NP_056240
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250}.
Subcellular Location Nucleus, nucleolus {ECO:0000250}.
Top Pathways Purine metabolism, RNA polymerase, Pyrimidine metabolism

RPA194 CRISPR/Cas9 KO Plasmid (h) - sc-400816 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA194 HDR Plasmid (h) - sc-400816-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA194 Double Nickase Plasmid (h) - sc-400816-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA194 Double Nickase Plasmid (h2) - sc-400816-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA194 CRISPR Activation Plasmid (h) - sc-400816-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA194 CRISPR Activation Plasmid (h2) - sc-400816-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA194 Lentiviral Activation Particles (h) - sc-400816-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA194 Lentiviral Activation Particles (h2) - sc-400816-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA194 siRNA (h) - sc-38244 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RPA194 shRNA Plasmid (h) - sc-38244-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RPA194 shRNA (h) Lentiviral Particles - sc-38244-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RPA70 RNAi - H00006117-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU005201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17106 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17106 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13075 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13075

POLR1A siRNA (Human) - CRH8563 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

POLR1A RNAi - H00025885-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human POLR1A (NM_015425.3) - SHH379320 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human POLR1A(NM_015425.3) - SHR127290 from Creative biogene

Category siRNA
Species Reactivities Human

POLR1A shRNA Plasmid (Human) - CHH8563 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

POLR1A miRNA 3'UTR clone - MiUTR1H-08070 from Creative biogene

Species Reactivities Human
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