POLR1A

Gene Symbol	POLR1A
Entrez Gene	25885
Alt Symbol	A190, RPA1, RPA194, RPO1-4, RPO14
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) I polypeptide A, 194kDa
Other Description	DNA-directed RNA polymerase I largest subunit|DNA-directed RNA polymerase I subunit A|DNA-directed RNA polymerase I subunit A1|DNA-directed RNA polymerase I subunit RPA1|RNA polymerase I 194 kDa subunit|RNA polymerase I subunit A1
Swissprots	Q0VG05 Q9UFT9 B7Z7T0 O95602 D6W5M0 Q9UEH0
Accessions	AAY24277 EAW99467 EAW99468 EAW99469 O95602 AK025568 BAB15171 AK294447 BAH11770 AK302458 BAH13716 AK304131 BAH14113 AK307490 AL117467 CAB55942 BC017115 AAH17115 BC073968 BC117173 AAI17174 BC126303 AAI26304 BC143345 AAI43346 BP363163 U33460 AAC99959 XM_006711983 XP_006712046 NM_015425 NP_056240
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus, nucleolus {ECO:0000250}.
Top Pathways	Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

POLR1A Antibody Blocking Peptide - LS-E6289 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RPA70 Protein - H00006117-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

POLR1A-Antibody-C-term-Blocking-Peptide - BP18976b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

POLR1A peptide - orb218467 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse

RPA1 Blocking Peptide - 33R-9194 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RPA1 Blocking Peptide - 33R-8749 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

POLR1A Blocking Peptide - abx063798 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

RPA1 Blocking Peptide - abx064201 from Abbexa Category Peptide Species Human, Mouse, Rat

RPA1 fusion protein - Ag14543 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human POLR1A, GST-tagged - POLR1A-1837H from Creative Biomart Category Protein Source E.coli Species Human

POLR1A Blocking Peptide - CBP2604 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Recombinant Human DNA-directed RNA polymerase I subunit RPA1(POLR1A) ,partial - CSB-YP018322HU CSB-EP018322HU CSB-BP018322HU CSB-MP018322HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

POLR1A Recombinant Protein Antigen - NBP2-32016PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RPA70 Protein - NBP1-89658PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

POLR1A Peptide, Human - M34GP12084H from Creative Peptides Category Peptide Source Synthetic. Species Human

RPA1 Peptide, Human - M34GP13479H from Creative Peptides Category Peptide Source Synthetic. Species Human

RPA70 Recombinant Protein Antigen - NBP2-55485PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

POLR1A Recombinant Protein Antigen - NBP2-56122PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA-directed RNA polymerase I subunit RPA1 (POLR1A), partial, Recombinant Protein - MBS1056774 from MyBioSource Category Protein Prices $1,090.00, $1,090.00, $1,320.00, $1,320.00, $1,665.00, $1,665.00, $2,125.00, $2,125.00, $2,160.00, $3,285.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RPA1 fusion protein - Ag26441 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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