| Gene Symbol |
POLR1A
|
| Entrez Gene |
25885
|
| Alt Symbol |
A190, RPA1, RPA194, RPO1-4, RPO14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) I polypeptide A, 194kDa
|
| Other Description |
DNA-directed RNA polymerase I largest subunit|DNA-directed RNA polymerase I subunit A|DNA-directed RNA polymerase I subunit A1|DNA-directed RNA polymerase I subunit RPA1|RNA polymerase I 194 kDa subunit|RNA polymerase I subunit A1
|
| Swissprots |
Q0VG05 Q9UFT9 B7Z7T0 O95602 D6W5M0 Q9UEH0
|
| Accessions |
AAY24277 EAW99467 EAW99468 EAW99469 O95602 AK025568 BAB15171 AK294447 BAH11770 AK302458 BAH13716 AK304131 BAH14113 AK307490 AL117467 CAB55942 BC017115 AAH17115 BC073968 BC117173 AAI17174 BC126303 AAI26304 BC143345 AAI43346 BP363163 U33460 AAC99959 XM_006711983 XP_006712046 NM_015425 NP_056240
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000250}.
|
| Top Pathways |
Purine metabolism, RNA polymerase, Pyrimidine metabolism
|