Gene Symbol | SRCAP |
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Entrez Gene | 10847 |
Alt Symbol | DOMO1, EAF1, FLHS, SWR1 |
Species | Human |
Gene Type | protein-coding |
Description | Snf2-related CREBBP activator protein |
Other Description | Snf2-related CBP activator protein|Swi2/Snf2-related ATPase homolog, domino homolog 1|domino homolog 2|helicase SRCAP |
Swissprots | Q6ZRS2 Q9Y5L9 Q7Z744 B0JZA6 O15026 |
Accessions | EAW52213 EAW52214 Q6ZRS2 AB621816 BAK64152 AF143946 AAD39760 AK023808 BAG51225 AK025382 AK126463 BAC86558 AK128030 BAC87237 AU140541 BC025284 BC063578 AAH63578 BC172428 AAI72428 BM677852 DA109400 NM_006662 NP_006653 |
Function | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00549, ECO:0000269|PubMed:10702287}. |
SRCAP CRISPR/Cas9 KO Plasmid (h) - sc-403049 from Santa Cruz Biotechnology
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SRCAP HDR Plasmid (h) - sc-403049-HDR from Santa Cruz Biotechnology
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SRCAP Double Nickase Plasmid (h) - sc-403049-NIC from Santa Cruz Biotechnology
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SRCAP Double Nickase Plasmid (h2) - sc-403049-NIC-2 from Santa Cruz Biotechnology
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SRCAP CRISPR Activation Plasmid (h) - sc-403049-ACT from Santa Cruz Biotechnology
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SRCAP CRISPR Activation Plasmid (h2) - sc-403049-ACT-2 from Santa Cruz Biotechnology
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SRCAP Lentiviral Activation Particles (h) - sc-403049-LAC from Santa Cruz Biotechnology
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SRCAP Lentiviral Activation Particles (h2) - sc-403049-LAC-2 from Santa Cruz Biotechnology
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SRCAP siRNA (h) - sc-93293 from Santa Cruz Biotechnology
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SRCAP shRNA Plasmid (h) - sc-93293-SH from Santa Cruz Biotechnology
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SRCAP shRNA (h) Lentiviral Particles - sc-93293-V from Santa Cruz Biotechnology
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SRCAP RNAi - H00010847-R01 from Novus Biologicals
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MISSION® esiRNA - EHU157301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20556 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20556 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03036 from Sigma-Aldrich
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SRCAP siRNA (Human) - CRH7387 from Cohesion Biosciences
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SRCAP - MBS826879 from MyBioSource
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shRNA set against Human SRCAP (NM_006662.2) - SHH417660 from Creative biogene
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Human SRCAP siRNA - orb267889 from Biorbyt
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SRCAP shRNA Plasmid (Human) - CHH7387 from Cohesion Biosciences
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SRCAP miRNA 3'UTR clone - MiUTR1H-09896 from Creative biogene
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