| Gene Symbol |
SRCAP
|
| Entrez Gene |
10847
|
| Alt Symbol |
DOMO1, EAF1, FLHS, SWR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Snf2-related CREBBP activator protein
|
| Other Description |
Snf2-related CBP activator protein|Swi2/Snf2-related ATPase homolog, domino homolog 1|domino homolog 2|helicase SRCAP
|
| Swissprots |
Q6ZRS2 Q9Y5L9 Q7Z744 B0JZA6 O15026
|
| Accessions |
EAW52213 EAW52214 Q6ZRS2 AB621816 BAK64152 AF143946 AAD39760 AK023808 BAG51225 AK025382 AK126463 BAC86558 AK128030 BAC87237 AU140541 BC025284 BC063578 AAH63578 BC172428 AAI72428 BM677852 DA109400 NM_006662 NP_006653
|
| Function |
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00549, ECO:0000269|PubMed:10702287}.
|